Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery
The Relationship Between Neurocognitive Changes and Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery
1 other identifier
observational
45
1 country
1
Brief Summary
In patients undergoing coronary artery bypass surgery, the relationship between neurocognitive changes seen in the early period and brain-induced neurotrophic factor serum levels will be investigated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 15, 2020
CompletedFirst Submitted
Initial submission to the registry
January 30, 2020
CompletedFirst Posted
Study publicly available on registry
January 31, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 15, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
October 15, 2020
CompletedDecember 3, 2020
December 1, 2020
7 months
January 30, 2020
December 2, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Postoperative cognitive dysfunction
Relationship between serum brain-derived neurotrophic factor level and cognitive dysfunction
4 days
Interventions
Mini Mental Test Those with a score below 21 points
Eligibility Criteria
Volunteer patients to be included in the study: 30 adult patients who will undergo coronary artery bypass grafting (CABG) surgery
You may qualify if:
- At Least Primary School Graduates,
- Not Using Drugs That May Affect Cognitive Functions,
- No Alcohol Substance Use,
- Without Psychiatric And Neurological Diseases
You may not qualify if:
- Uneducated Patients,
- Drug Users Who May Affect Cognitive Functions (Antipsychotic, Antidepressant),
- Have Alcohol And Substance Use Disorders,
- Those With A History Of Central Nervous System Disease That May Cause Cognitive Dysfunction (Such As Stroke, Neurodegenerative Disease, Seizure, General Anxiety),
- Hearing Deficit,
- Patients With Unilateral Carotid Artery Stenosis Greater Than 70% And Bilateral Stenosis Greater than 50% Carotid Artery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bozok Universitylead
Study Sites (1)
Bozok University Medical Center
Yozgat, Turkey (Türkiye)
Related Publications (1)
Miniksar OH, Cicekcioglu F, Kilic M, Honca M, Miniksar DY, Gocmen AY, Kacmaz O, Oz H. Decreased brain-derived neurotrophic factor levels may predict early perioperative neurocognitive disorder in patients undergoing coronary artery bypass surgery: A prospective observational pilot study. J Clin Anesth. 2021 Aug;71:110235. doi: 10.1016/j.jclinane.2021.110235. Epub 2021 Mar 25.
PMID: 33774438DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Yozgat Bozok University Research Hospital
Yozgat
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Asist.Prof.
Study Record Dates
First Submitted
January 30, 2020
First Posted
January 31, 2020
Study Start
January 15, 2020
Primary Completion
August 15, 2020
Study Completion
October 15, 2020
Last Updated
December 3, 2020
Record last verified: 2020-12
Data Sharing
- IPD Sharing
- Will not share
Can be announced after the work is completed.