Effects of Fish Oil and Resistance Training on Muscle Mass and Function

NCT04245332 | Suspended

• 1 other identifier: Pro2019000649
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study consists of a free-living, 6-week fish oil (FO) or placebo (PLA) supplementation intervention alongside participants' habitual resistance exercise training (RET) regimens. Twenty young, healthy resistance-trained subjects who do not currently supplement with FO will be recruited to participate. An eligible participant will be between ages 18 and 35 and will have a minimum of two years of RET experience. Participants will be randomized into a FO group and a PLA group. The FO group will supplement with 4g/day of FO (4g fish oil concentrate: 2g EPA+ 1g DHA) and the PLA group will consume 4g/day of coconut oil (saturated fatty acids), as administered via gel capsules, in conjunction with their current RET program. Prior to intervention all participants will complete baseline biometric, strength, and neuromuscular testing. Participants will also have blood drawn to test for omega-3 fatty acid status, and complete and return a 3-day diet record and a physical activity recall. In order to monitor adherence to supplementation, FO and PLA bottles will also be returned weekly and pills will be counted. 3-day diet records will be obtained to ensure calorie and protein intakes remain consistent throughout the intervention period. Weekly physical activity records will also help to ensure consistency of participant training and to make sure all participants are following their training regimes in a progressive fashion. Following 6 weeks of FO or PLA supplementation, subjects will repeat all initial biometric, strength and neuromuscular testing, as well as a second, post-intervention blood draw.

Conditions

Fat-free Masss; Muscle Strength; Neuromuscular Function

Outcome Measures

Primary Outcomes (4)

• Total body fat-free mass (FFM)

  Measured by bioelectrical impedance analysis (BIA)

  6 weeks

• Muscle strength

  Measured by one-repetition maximal (1RM) strength in back squat, bench press, and knee extensor

  6 weeks

• Rate of force development (RFD)

  Assessed by force transducers on legs and in hands

  6 weeks

• Maximal voluntary contraction (MVC)

  Assessed by force transducers on legs and in hands

  6 weeks

Secondary Outcomes (1)

• Red blood cell omega-3 fatty acid concentrations (Eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA])

  6 weeks

Study Arms (2)

Fish Oil

EXPERIMENTAL

This group will receive fish oil (4g/d).

Dietary Supplement: Fish oil

Placebo

PLACEBO COMPARATOR

This group will receive coconut oil (4g/d) as an iso-energetic, iso-lipidic placebo comparator to the fish oil arm.

Dietary Supplement: Coconut oil

Interventions

Fish oil DIETARY_SUPPLEMENT

Fish oil-derived omega-3 polyunsaturated fatty acids (4g fish oil concentrate: 2g EPA+ 1g DHA)

Also known as: NOW Foods Ultra Omega-3

Fish Oil

Coconut oil DIETARY_SUPPLEMENT

Coconut oil (4g/d)

Also known as: NOW Foods Virgin Coconut Oil Softgels

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Young, healthy, resistance-trained men and women of all nationalities between the ages of 18-35

You may not qualify if:

• metabolic disease (diabetes or metabolic syndrome)
• cardiovascular disease
• pulmonary disease
• chronic inflammatory conditions (e.g. renal/kidney, liver, asthma, arthritis, autoimmune diseases, inflammatory bowel disease)
• neurological conditions (e.g. Parkinson's)
• sexually transmitted diseases
• cancer diagnosis within the previous 5 years
• currently smoking cigarettes
• hypertension
• hypercholesterolemia and/or dyslipidemia
• using medications to manage cholesterol, blood lipids, blood pressure, or diabetes
• taking performance-enhancing drugs and/or anabolic agents (e.g. testosterone, growth hormone, or beta-2 agonists)
• oral contraceptive use, are pregnant, or intend to become pregnant while enrolled in the study
• fish oil supplement use within the past 6 months
• fasting blood total cholesterol concentration \>200mg/dl

Sponsors & Collaborators

• Rowan University: lead

Study Sites (1)

Rowan University

Glassboro, New Jersey, 08028, United States

Location

MeSH Terms

Interventions

Fish Oils; Coconut Oil

Intervention Hierarchy (Ancestors)

Oils; Lipids; Dietary Fats; Fats; Plant Oils

Study Officials

• Dylan Klein, Ph.D.

  Rowan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2020
• First Posted: January 28, 2020
• Study Start: January 29, 2020
• Primary Completion: June 30, 2021
• Study Completion: September 30, 2021
• Last Updated: March 10, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)