Prophylactic Treatment of Skin Rash Associated With EGFR Inhibitor Therapy

NCT04239846 | Completed Phase 2

• 1 other identifier: AC-701-ONC-002
• Study Type: interventional
• Target: 74
• Locations: 1 country
• Sites: 2

Brief Summary

Epidermal growth factor receptor inhibitor (EGFRI) therapy for cancer is associated with potentially severe face and trunk skin acneiform rash. Severe or persistent side effects may lead to decreased dose, interruption or discontinuation of EGFRI treatment. Inflammation is believed to play an important role in EGFRI-induced skin toxicity as a number of proinflammatory cytokines induced by EGFRI are released from epidermal cells, resulting in activation and recruitment of immune cells such as neutrophils and lymphocytes, and subsequent development of skin reaction associated with keratinocyte apoptosis. AC-701 has been reported its antibiotic and anti-inflammatory activities in literature, and further demonstrated in vitro effect to prevent the secretion of inflammatory cytokines associated with EGFR inhibition. This study is to evaluate the prophylactic efficacy of topical AC-701 in subjects with skin rash associated with EGFRI therapy.

Conditions

EGFR Inhibitor-Induced Skin Rash

Outcome Measures

Primary Outcomes (1)

• Number of subjects with MESTT Grade 0 or 1

  Week 4

Study Arms (2)

AC-701

EXPERIMENTAL

AC-701 Topical Gel 0.3%

Drug: AC-701 Topical Gel 0.3%

Placebo

PLACEBO COMPARATOR

Placebo Gel

Other: Placebo Gel

Interventions

AC-701 Topical Gel 0.3% DRUG

AC-701 Topical Gel 0.3%, BID

Also known as: AC-701

AC-701

Placebo Gel OTHER

Placebo Gel, BID

Also known as: Placebo control

Placebo

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Is between 20 and 80 years of age, inclusive.
• Patients who are within ±3 days of initiating EGFR inhibitor therapy using afatinib or erlotinib, and have no prior history of using afatinib or erlotinib within 6 months.
• Has a life expectancy of at least three months.

You may not qualify if:

• Has any active dermatological conditions of the face that may interfere with the diagnosis, assessment, or treatment of face skin rash associated with targeted cancer therapy.
• Has been treated with steroids (systemic or topical on face) to the face within 7 days prior to Day 1.
• Patients who have been treated with oral antibiotics that known to exert anti-inflammatory effect (such as doxycycline or minocycline) within 7 days prior to Day 1.
• Is currently treated with target therapy other than afatinib or erlotinib.
• Receive prior treatment with any investigational product within 28 days prior to Day 1.
• Has hypersensitivity or allergy to the study medication.
• Has any other significant diseases, conditions, or laboratory values which, in the opinion of the investigator, might make participation not in the subject's best interest or confound the interpretation of study results.

Sponsors & Collaborators

• TWi Biotechnology, Inc.: lead

Study Sites (2)

Taipei Veterans General Hospital

Taipei, Taiwan

Location

Chang Gung Memorial Hospital

Taoyuan District, Taiwan

Location

Study Officials

• Emily Lin

  TWi Biotechnology, Inc.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2020
• First Posted: January 27, 2020
• Study Start: October 2, 2019
• Primary Completion: May 12, 2021
• Study Completion: May 26, 2021
• Last Updated: April 27, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

TW (2)