Reward and Punishment Sensitivity in Bipolar Disorders
Recodec-BP
2 other identifiers
observational
90
1 country
1
Brief Summary
Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical settings. Whereas distinguishing BD-I and BD-II main subtypes has a significant relevance for treatment strategy and for outcome, there are currently no clinical determinants of the BD subtype which could be used as early diagnostic predictors.
- While neurobiological specificity of each BD subtype is still controversial, available evidence suggest different dopaminergic abnormalities in each subtype. Dopaminergic function is involved in decision making and reward processing which may represent useful BD subtype markers.
- This study aims at assessing decision making during appetitive and punitive reinforcement learning in patients with BD I and BD II subtypes compared to healthy controls
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 10, 2020
CompletedFirst Posted
Study publicly available on registry
January 23, 2020
CompletedStudy Start
First participant enrolled
February 24, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 23, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
February 23, 2022
CompletedSeptember 4, 2020
September 1, 2020
2 years
January 10, 2020
September 3, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Response performance in reward and loss trials
percentage of correct responses in the probabilistic learning task
one day visit
Study Arms (3)
Bipolar disorder type I
Bipolar disorder type II
healthy controls
Interventions
Probabilistic learning task
Eligibility Criteria
Patients with bipolar disorder, type I and II, in a inter critical phase (euthymic period defined by the mood scales scores mentioned in the inclusion criteria)
You may qualify if:
- bipolar disorder (BD) type I or II, according to DSM (Diagnostic and Statistical Manual)-5 criteria
- Montgomery and Asberg Depression Rating Scale (MADRS) score \< 15
- Young Mania Rating Scale (YMRS) score \< 12
You may not qualify if:
- other main diagnosis than bipolar disorder
- other medical condition leading to cognitive deterioration
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chu Grenoble Alpes
Grenoble, 38043, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 10, 2020
First Posted
January 23, 2020
Study Start
February 24, 2020
Primary Completion
February 23, 2022
Study Completion
February 23, 2022
Last Updated
September 4, 2020
Record last verified: 2020-09
Data Sharing
- IPD Sharing
- Will not share