At-home Transcranial Alternating Current Stimulation During Multitasking

NCT04231825 | Completed Results DMC FDA Device

• 1 other identifier: 18-26268-1
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

The goal is to replicate in-lab results from transcranial alternating current stimulation (tACS) with at-home tACS.

Conditions

Multitasking Behavior

Outcome Measures

Primary Outcomes (3)

• Multitasking Performance Cost (Neuroracer Performance Change From Baseline)

  Assessment of multitasking ability using change from baseline scores in d' cost (metric of discriminability). Discrimination performance (d') was measured for each participant by comparing hit (correct responses to target signs) rates and false alarm (responses to non-targets) rates and calculated as d' = Z (hits) - Z (false alarms). d' cost was then calculated as the ratio of d' during single task target discrimination task to multitask target discrimination, expressed as percentage cost.

  Pre-tACS and post-tACS (1 week later)

• Single Task Performance Change

  Discrimination performance (d') was measured during single task performance for each participant by comparing hit (correct responses to target signs) rates and false alarm (responses to non-targets) rates and calculated as d' = Z (hits) - Z (false alarms). Performance data was collected during the single task condition.

  Pre-tACS and post-tACS (1 week later)

• Multitask Performance Change

  Discrimination performance (d') was measured while multitasking for each participant by comparing hit (correct responses to target signs) rates and false alarm (responses to non-targets) rates and calculated as d' = Z (hits) - Z (false alarms). Performance data was collected during the multitask condition.

  Pre-tACS and post-tACS (1 week later)

Secondary Outcomes (2)

• Continuous Performance Test RT Change (Test of Visual Attention / Sustained Attention)

  Pre-tACS and post-tACS (1 week later)

• Continuous Performance Test RTV Change (Test of Visual Attention / Sustained Attention)

  Pre-tACS and post-tACS (1 week later)

Study Arms (2)

Verum Stimulation

EXPERIMENTAL

This group will receive 6-Hz tACS

Device: Transcranial alternating current stimulation

Frequency Control

ACTIVE COMPARATOR

This group will receive 1-Hz tACS

Device: Transcranial alternating current stimulation

Interventions

Transcranial alternating current stimulation DEVICE

Transcranial alternating current stimulation across the prefrontal cortex using electrodes F3 and F4.

Frequency Control; Verum Stimulation

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• English speaking
• Grade 12 or more education
• Normal or corrected to normal vision and hearing
• Ability to complete cognitive tasks
• Ability to cooperate and comply with all study procedures
• Ability to tolerate tACS

You may not qualify if:

• Neurological or psychiatric disorders
• Family history of epilepsy
• History of seizures
• Prior head trauma
• Pregnant
• Implanted electronic devices (e.g., pacemaker)
• IQ \< 80
• Taking psychotropic medication
• Taking anti-depressants or anti-anxiety medication
• Substance abuse
• Color blind
• Glaucoma
• Macular degeneration
• Amblyopia
• Strabismus

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

Sandler Neurosciences Center

San Francisco, California, 94158, United States

Location

MeSH Terms

Conditions

Multitasking Behavior

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Results Point of Contact

• Title: Dr. Theodore Zanto
• Organization: University of California San Francisco

theodore.zanto@ucsf.edu

415-502-7322

Study Officials

• Theodore Zanto, Ph.D.

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 8, 2019
• First Posted: January 18, 2020
• Study Start: October 15, 2019
• Primary Completion: August 15, 2020
• Study Completion: September 15, 2020
• Last Updated: March 21, 2022
• Results First Posted: October 28, 2021

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: The data will be available after the results have been determined and the study researchers are unblinded. The data will be available indefinitely upon request.
• Access Criteria: Contact PI.

Locations

US (1)