Periodontal Regeneration vs Extraction and Replacement of Teeth Severely Compromised by Attachment Loss to the Apex: a 10-year RCT
Sponsor study identifier
interventional
50
1 country
1
Study Start
June 1, 1998
Actual (reported)Primary Completion
December 31, 2014
Actual (reported)Study Completion
December 31, 2014
Actual (reported)Periodontal regeneration can change tooth prognosis and represents an alternative to extraction in teeth compromised by severe intrabony defects. The aim of this study is to compare periodontal regeneration (PR) with tooth extraction and replacement (TER) in a population with attachment loss to or beyond the apex of the root in terms of professional, patient reported and economic outcomes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2014
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 1, 1998
Actual (reported)December 31, 2014
Actual (reported)December 31, 2014
Actual (reported)January 9, 2020
Actual (reported)January 14, 2020
Actual (reported)Tooth or tooth replacement survival
Presence of functional and symptoms free tooth or tooth replacement
10 year
Occurrence and cost of management of recurrence
Recurrence analysis
10-year
Oral health related quality of life: OHIP-14 (Oral Health Impact Profile)
14 validated questions, 5 point Liker scale, smaller scores represent better outcome (smaller impact on quality of life)
10 years
Clinical attachment level gain
10 years
Probing pocket depth
10 years
Periodontal regeneration consisting of papilla preservation flaps, application of FDA approved CE marked periodontal regenerative devices, tooth splinting and root canal treatment as required.
Tooth extraction and replacement with a dental implant or a fixed partial denture following healing and reconstruction of the extraction area. Choice based on standard of practice.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Faculty of Dentistry, The University of Hong Kong
Hong Kong, Hong Kong
Cortellini P, Stalpers G, Mollo A, Tonetti MS. Periodontal regeneration versus extraction and dental implant or prosthetic replacement of teeth severely compromised by attachment loss to the apex: A randomized controlled clinical trial reporting 10-year outcomes, survival analysis and mean cumulative cost of recurrence. J Clin Periodontol. 2020 Jun;47(6):768-776. doi: 10.1111/jcpe.13289. Epub 2020 Apr 19.
Pierpaolo Cortellini, MD
Investigator
50 participants (actual enrollment reported by the registry).
First Submitted
January 9, 2020
First Posted
January 14, 2020
Study Start
June 1, 1998
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
December 31, 2014
Actual (reported)Study Completion
December 31, 2014
Actual (reported)Last Updated
January 14, 2020
Record last verified: 2020-01
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: