Reference Values for Compound Muscle Action Potential Amplitude Obtained by Direct Muscle Stimulation

NCT04227548 | Completed

• 1 other identifier: 30/401
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Direct muscle stimulation (DMS) method is one of the electrodiagnostic methods used in the diagnosis of critical illness myopathy (CIM) and critical illness neuropathy (CIN). The ratio of amplitude of compound muscle action potential (CMAP) obtained by nerve stimulation (nCMAP) to amplitude of CMAP obtained by DMS (dmCMAP) can be used to differentiate these two diseases. Although not certain, if the ratio is \< 0.5, the diagnosis is thought to be consistent with CIN. The ratio \> 0.5 is considered to be a finding supporting CIM. The investigators aimed to find the reference values of the ratio from healthy individuals. A monopolar needle electrode was used for DMS. The dmCMAP and nCMAP were recorded with a concentric needle. The ratio was calculated by using amplitudes of dmCMAP and nCMAP obtained from deltoid and tibialis anterior muscles.

Conditions

Critical Illness Polyneuromyopathy

Keywords

Critical illness myopathy; Critical illness neuropathy; direct muscle stimulation

Outcome Measures

Primary Outcomes (1)

• the Ratio of Compound Muscle Action Potential Amplitude Obtained by Nerve Stimulation to That Obtained by Direct Muscle Stimulation

  The normal limits of the ratio were the primary outcome criteria. This ratio is high in critical illness myopathy or healthy individuals, while low in ciritical illness neuropathy of broken disease occurs. Considering the study of Lefaucheur et al., at least 23 healthy individuals should be included in the study.(Lefaucheur JP, Nordine T, Rodriguez P, Brochard L (2006) Origin of ICU acquired paresis determined by direct muscle stimulation. J Neurol Neurosurg Psychiatry 77:500-6)

  1 hour

Study Arms (1)

Healthy individuals

EXPERIMENTAL

Diagnostic Test: needle electromyography

Interventions

needle electromyography DIAGNOSTIC_TEST

Direct muscle stimulation was performed to deltoid and tibialis anterior muscles with a monopolar needle electrode. Recording was made with a concentric needle electrode.

Healthy individuals

Eligibility Criteria

• Age: 15 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy individuals

You may not qualify if:

• Polyneuropathy
• a disease such as diabetes mellitus that causes polyneuropathy
• complaints such as weakness or paresthesia
• a neurodegenerative disease
• abnormal neurological examination

Sponsors & Collaborators

• Adana City Training and Research Hospital: lead

Study Sites (1)

Adana City Training and Research Hospital

Adana, 01230, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor, Neurology and Clinical Neurophysiology

Study Record Dates

• First Submitted: January 9, 2020
• First Posted: January 13, 2020
• Study Start: April 30, 2019
• Primary Completion: December 2, 2019
• Study Completion: December 30, 2019
• Last Updated: January 13, 2020

Record last verified: 2020-01

Locations

TU (1)