NCT04223726

Brief Summary

CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
210

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2013

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 22, 2013

Completed
6.3 years until next milestone

First Submitted

Initial submission to the registry

December 10, 2019

Completed
1 month until next milestone

First Posted

Study publicly available on registry

January 10, 2020

Completed
6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

April 25, 2024

Status Verified

April 1, 2024

Enrollment Period

12.4 years

First QC Date

December 10, 2019

Last Update Submit

April 24, 2024

Conditions

Kidney DiseasesCardiovascular Diseases

Keywords

chronic kidney diseasequality of life

Outcome Measures

Primary Outcomes (2)

  • Mortality

    5 years

  • Cardiovascular morbidity

    5 years

Secondary Outcomes (11)

  • Changes in quality of life

    2 years, 5 years

  • Number of participants with cardiac arrhythmias

    2 years, 5 years

  • Rate of hospitalizations

    2 years, 5 years

  • Abdominal aortic calcification (AAC) score

    2 years, 5 years

  • Carotid intima-media thickness

    2 years, 5 years

  • +6 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients referred to the Predialysis outpatient clinic in Turku University Hospital Kidney Center

You may qualify if:

  • estimated glomerular filtration rate \< 30 ml/min per 1.73 m\^2

You may not qualify if:

  • age under 18 years
  • inability to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Turku University Hospital

Turku, Finland

Location

Related Publications (1)

  • Lankinen R, Hakamaki M, Metsarinne K, Koivuviita N, Parkka JP, Saarenhovi M, Hellman T, Jarvisalo MJ. Association of maximal stress ergometry performance with troponin T and abdominal aortic calcification score in advanced chronic kidney disease. BMC Nephrol. 2021 Feb 4;22(1):50. doi: 10.1186/s12882-021-02251-y.

    PMID: 33541279DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, serum, plasma

MeSH Terms

Conditions

Kidney DiseasesCardiovascular DiseasesRenal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesRenal InsufficiencyChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Kaj Metsärinne, MD, PhD

    Turku University Hospital Kidney Center

    PRINCIPAL INVESTIGATOR

  • Mikko J Järvisalo, MD, PhD

    Turku University Hospital Intensive Care Unit

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 10, 2019

First Posted

January 10, 2020

Study Start

August 22, 2013

Primary Completion

December 31, 2025

Study Completion

December 31, 2025

Last Updated

April 25, 2024

Record last verified: 2024-04

Data Sharing

IPD Sharing
Will not share

Locations

FI(1)