NCT04216017

Brief Summary

The objective of this project is to determine if giving a cortisone injection to patients with proximal humerus fractures who have stiff shoulders recover their range of motion.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
9

participants targeted

Target at below P25 for phase_2

Timeline
Completed

Started Jan 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 24, 2019

Completed
8 days until next milestone

Study Start

First participant enrolled

January 1, 2020

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 2, 2020

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2022

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2022

Completed
1.4 years until next milestone

Results Posted

Study results publicly available

September 26, 2023

Completed
Last Updated

September 26, 2023

Status Verified

August 1, 2023

Enrollment Period

2.2 years

First QC Date

December 24, 2019

Results QC Date

February 2, 2023

Last Update Submit

August 31, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • American Shoulder Elbow Society Score

    Outcome Instrument high is good low is bad 0-100 The ASES is a condition-specific scale that is intended to measure functional limitations and pain of the shoulder.

    24 weeks

Secondary Outcomes (1)

  • Visual Analogue Scale

    24 weeks

Study Arms (2)

Controls

PLACEBO COMPARATOR

Patients receiving lidocaine

Drug: Lidocaine

Cases

ACTIVE COMPARATOR

Patients receiving Kenalog

Drug: kenalog

Interventions

Cortisone injection into shoulder

Cases

Lidocaine injection into shoulder

Controls

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \. Proximal Humerus Fracture
  • \. Decreased range of motion at 6 wk follow-up
  • \. Likely to be available for follow up for 26 wks

You may not qualify if:

  • Known drug allergy to kenalog or lidocaine
  • Unable to complete functional outcome
  • Pregnant Women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Washington

Seattle, Washington, 98104, United States

Location

MeSH Terms

Conditions

Humeral Fractures

Interventions

Triamcinolone AcetonideLidocaine

Condition Hierarchy (Ancestors)

Arm InjuriesWounds and InjuriesFractures, Bone

Intervention Hierarchy (Ancestors)

TriamcinolonePregnadienesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsSteroids, FluorinatedAcetanilidesAnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Results Point of Contact

Title
Dr. Jonah Hebert-Davies
Organization
University of Washington

Study Officials

  • Jonah Hebert-Davies, MD

    University of Washington

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor, School of Medicine: Orthopedics

Study Record Dates

First Submitted

December 24, 2019

First Posted

January 2, 2020

Study Start

January 1, 2020

Primary Completion

April 1, 2022

Study Completion

May 1, 2022

Last Updated

September 26, 2023

Results First Posted

September 26, 2023

Record last verified: 2023-08

Data Sharing

IPD Sharing
Will not share

Locations