Chewing and Swallowing Training Program in Coffin-Lowry Syndrome

NCT04199546 | Completed

• 1 other identifier: KA-94678
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

This study will report the chewing and swallowing disorders of a Coffin-Lowry Syndrome (CLS) patient, and effects of chewing and swallowing training on chewing and swallowing function.

Conditions

Swallowing Disorder; Chewing Problem

Outcome Measures

Primary Outcomes (1)

• Instrumental swallowing evaluation

  Videofluoroscopic Swallowing Evaluation (VFSE) will be performed. The swallowing physiology will be evaluated by using 3 ml of liquid and pudding barium during the VFSE. The Penetration and Aspiration Scale (PAS) will be used to determine penetration and aspiration severity, which is scored between 1 to 8. The score of PAS 1 means 'No aspiration', scores from 2 to 5 indicate 'Penetration', and scores from 6 to 8 indicate 'Aspiration'. High score indicates bad situation.

  6 months

Secondary Outcomes (2)

• Swallowing screening

  6 months

• Chewing evaluation

  6 months

Study Arms (1)

A child with Coffin-Lowry Syndrome

OTHER

A boy with a known CLS diagnosis with a history of coughing during eating, long-lasting wheezing, sputum and inability to intake solid food will be included.

Other: Chewing and swallowing rehabilitation

Interventions

Chewing and swallowing rehabilitation OTHER

A home based chewing and swallowing training program (CST) will be applied by an experienced physical therapist. The Functional Chewing Training will be used to improve chewing function which has five steps including positioning the child and food, sensory stimulation, chewing training and adjustment of food consistency to improve chewing function. To support hyolaryngeal elevation, laryngeal mobilization will be performed. Hyolaryngeal mobilization will be performed by moving hyolaryngeal complex in right, left and up directions manually.

A child with Coffin-Lowry Syndrome

Eligibility Criteria

• Age: 3 Years - 3 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Having a diagnosis of CLS
• Having a history of coughing during eating, long-lasting wheezing, sputum
• Inability to intake solid food.

You may not qualify if:

• \- No history of coughing during eating, long-lasting wheezing, sputum

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Deglutition Disorders

Interventions

Mastication

Condition Hierarchy (Ancestors)

Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Pharyngeal Diseases; Otorhinolaryngologic Diseases

Intervention Hierarchy (Ancestors)

Eating; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Digestive System Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Officials

• AYŞE KÜBRA ŞAHAN

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 12, 2019
• First Posted: December 16, 2019
• Study Start: December 12, 2019
• Primary Completion: June 19, 2020
• Study Completion: June 19, 2020
• Last Updated: July 1, 2020

Record last verified: 2020-06

Locations

TU (1)