Chest Dysphoria in Transmasculine Spectrum Adolescents
The Effect of Top Surgery on Chest Dysphoria in Assigned-Female-At-Birth, Transmasculine Spectrum Youth and Young Adults
1 other identifier
observational
81
1 country
3
Brief Summary
The investigators hypothesize that masculinizing top surgery (e.g., mastectomy and chest masculinization) leads to an improvement in self-report chest dysphoria, gender dysphoria, and gender congruence in assigned-female-at-birth, transgender and non-binary youth and young adults. This is a prospective, observational study that will enroll assigned-female-at-birth, transmasculine spectrum individuals age 13 to 25 years old who are or are not undergoing top surgery. Participants will complete a set of standard of care questionnaires regarding their chest dysphoria (e.g., distress about the chest), gender dysphoria (e.g., distress about a gender identity that does not match assigned sex), and gender congruence (e.g., degree to which an individual feels they are living in their authentic appearance and gender identity). They will complete this same set of questionnaires either three months after their top surgery or three months after the initial set of surveys.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2019
Typical duration for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 29, 2019
CompletedFirst Submitted
Initial submission to the registry
December 10, 2019
CompletedFirst Posted
Study publicly available on registry
December 12, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2021
CompletedJune 10, 2022
June 1, 2022
2.2 years
December 10, 2019
June 8, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Chest Dysphoria
The disruption of individual comfort, physical functioning, and interpersonal relationships from a chest with breasts, as measured by the Chest Dysphoria Measure (Score 0-51, Higher number means greater chest dysphoria)
Three month
Secondary Outcomes (2)
Gender Dysphoria
Three month
Gender Congruence
Three month
Study Arms (2)
Top Surgery
Individuals assigned the female sex at birth, who identify as a gender other than female, are between the ages of 13 and 25 years, and who are undergoing mastectomy and chest masculinization in one of three plastic surgery practices in Chicago.
Control
Individuals assigned the female sex at birth, who identify as a gender other than female, are between the ages of 13 and 25 years, were seen in a gender development clinic in Chicago, and who are not planning to undergo top surgery. Controls will be matched with top surgery patients on age and number of months of testosterone.
Interventions
A surgical procedure in which the breasts are removed and the chest is given a masculine contour.
Eligibility Criteria
Top surgery participants will be recruited from plastic surgery practices at Northwestern University, the Ann and Robert H Lurie Children's Hospital of Chicago, and the University of Illinois Chicago. Matched controls will be recruited from the Lurie Children's Hospital Gender and Sex Development Program.
You may qualify if:
- Assigned the female sex at birth
- Affirmed gender identity of male, non-binary, or gender other than female
- English-speaking
- Undergoing top surgery or matches a top surgery participant on age and number of months on testosterone
You may not qualify if:
- Non English speaking
- Unable to complete self-report questionnaires
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Northwestern Universitylead
- Ann and Robert H. Lurie Children's Hospital of Chicagocollaborator
- University of Illinois at Chicagocollaborator
Study Sites (3)
Ann and Robert H Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
Northwestern University
Chicago, Illinois, 60611, United States
University of Illinois Chicago
Chicago, Illinois, 60612, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sumanas W Jordan, MD PhD
Northwestern University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
December 10, 2019
First Posted
December 12, 2019
Study Start
October 29, 2019
Primary Completion
December 31, 2021
Study Completion
December 31, 2021
Last Updated
June 10, 2022
Record last verified: 2022-06