Trials Sponsors Conditions Drugs Pricing

Conditions

Insulin Resistance Overweight and Obesity

Outcome Measures

Primary Outcomes (1)

Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise
Percent change in serum myostatin levels from pre- to 3 hours post-cardiopulmonary exercise test
Pre- to 3 hours post-exercise

Secondary Outcomes (2)

Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise
Pre- to 2 hours post-exercise
Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise
Immediately post to 2 hours post-exercise

Study Arms (1)

Cardiopulmonary exercise testing

Procedure: Cardiopulmonary exercise test (CPET)

Interventions

Cardiopulmonary exercise test (CPET)Procedure

CPET studies will be performed in the Cardiovascular Performance Program exercise lab at MGH. Subjects will undergo CPET on an upright cycle ergometer with continual measurement of metabolic gas exchange via a commercially available metabolic cart as well as heart rate and blood pressure. Exercise will proceed according to a maximal effort clinical protocol. Subjects will then undergo a standardized 30-min work load on the upright cycle ergometer based on the results of the maximal effort clinical protocol.

Cardiopulmonary exercise testing

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Adults with overweight or obesity

You may qualify if:

Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)

You may not qualify if:

Sponsors & Collaborators

Massachusetts General Hospital
Otherlead

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

MeSH Terms

Conditions

OverweightObesityInsulin Resistance

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsHyperinsulinismGlucose Metabolism DisordersMetabolic Diseases

Intervention Hierarchy (Ancestors)

Results Point of Contact

Title: Melanie S. Haines, MD
Organization: Massachusetts General Hospital

Study Officials

Melanie S Haines, MD
Massachusetts General Hospital
PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee: No
Restrictive Agreement: No

Enrollment

28 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

December 9, 2019

First Posted

December 11, 2019

Study Start

December 12, 2019

Actual (reported)

Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Results Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Cardiopulmonary exercise testing

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Results Point of Contact

Study Officials

Publication Agreements

Enrollment

Study Design

Study Record Dates

Source record

Documents

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Results Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Cardiopulmonary exercise testing

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Results Point of Contact

Study Officials

Publication Agreements

Enrollment

Study Design

Study Record Dates

Source record

Documents

Locations