Development of a Prognostic Tool for the Stratification of Cardiovascular Risk in Patients With Ischemic Stroke

NCT04189497 | Completed

• 1 other identifier: 25126/03-06-19
• Study Type: observational
• Target: 3,500
• Locations: 1 country
• Sites: 1

Brief Summary

The availability of several high-cost strategies for the prevention of cardiovascular morbidity and mortality in patients with established cardiovascular disease highlights the necessity of reliable risk stratification of these patients. Several such prognostic models are available for patients with coronary artery disease; however, for patients with ischemic stroke, the available risk stratification schemes are very few and have several limitations. This study aims to develop a prognostication tool to stratify the risk of cardiovascular outcomes in patients with ischemic stroke. The development of a well-designed prognostication tool for the stratification of cardiovascular risk in patients with ischemic stroke may assist to the identification of the highest-risk patients and hence, provide useful information to clinicians and authoritative bodies when prioritizing high-cost strategies for secondary stroke prevention.

Conditions

Stroke, Ischemic; Cardiovascular Risk Factor; Cardiovascular Diseases; Cardiovascular Morbidity

Keywords

Ischemic Stroke; Risk stratification; Cardiovascular events

Outcome Measures

Primary Outcomes (1)

• A well-validated prognostication tool for the stratification of the risk of major adverse cardiovascular events in patients with ischemic stroke regardless of the underlying etiology or the pathophysiologic mechanism of the index stroke

  The primary outcome of the study is to built a prognostication tool, in order to predict which stroke patients are going to have the highest risk of secondary major cardiovascular events

  prognostication tool for major cardiovascular adverse events reported during the follow up period, up to 10 years

Eligibility Criteria

• Age: 18 Years - 130 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This will be a retrospective analysis in the Athens Stroke Registry, which is a prospective registry of all patients with acute first-ever ischemic stroke admitted between 1993 and 2010 within 24 hours after stroke onset and followed up for up to 10 years.The Athens Stroke Registry has supported many research projects with high-quality publications in high-profile journals, some of them may be found here. We expect that the dataset will include all eligible patients, i.e. approximately 3500 patients with ischemic stroke. The dataset will lock the day before the initiation of the study.

You may qualify if:

• All patients with acute ischemic stroke registered in the Athens Stroke registry will be included in the analysis regardless of the underlying etiology or pathophysiologic mechanism

You may not qualify if:

• Patients with intracranial haemorrhage or transient ischemic attack

Sponsors & Collaborators

• University of Thessaly: lead

Study Sites (1)

University of Thessaly

Larissa, 41110, Greece

Location

Related Publications (18)

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  PMID: 27222591 RESULT

MeSH Terms

Conditions

Ischemic Stroke; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Medicine

Study Record Dates

• First Submitted: November 28, 2019
• First Posted: December 6, 2019
• Study Start: June 30, 2019
• Primary Completion: June 30, 2019
• Study Completion: November 20, 2019
• Last Updated: December 6, 2019

Record last verified: 2019-12

Locations

GR (1)