Time Lag for Oocyte Denudation: A Better Choice for ICSI Outcome?!
1 other identifier
observational
300
1 country
1
Brief Summary
This study aiming to investigate if difference in the timing of cumulus removal post retrieval would have any critical impact on fertilization and embryonic development.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2019
CompletedFirst Submitted
Initial submission to the registry
December 1, 2019
CompletedFirst Posted
Study publicly available on registry
December 4, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedSeptember 21, 2022
September 1, 2022
1.3 years
December 1, 2019
September 18, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Day 5, good quality blastocyst
Assessment were done according to gardener classification
120 hour post ovum pickup
Secondary Outcomes (1)
clinical pregnancy
6 weeks from the last normal menstrual period
Study Arms (2)
Group A (immediate denudation)
Oocytes were denudated immediately after oocyte retrieval and were microinjected at 4 hours from ovum pickup. Microinjection was performed on all matured oocytes only and they were cultured to blastocyst stage.The rates of maturation, fertilization, good quality blastulation, chemical pregnancy and clinical pregnancy were analysed and compared between the two groups.
Group B ( 2hs denudation after ovum pickup)
Oocytes were denudated 2 hours after retrieval and were microinjected at 4 hours from ovum pickup. Microinjection was performed on all matured oocytes only and they were cultured to blastocyst stage.The rates of maturation, fertilization, good quality blastulation, chemical pregnancy and clinical pregnancy were analysed and compared between the two groups.
Interventions
The time between ovum pickup and denudation of oocyte
Eligibility Criteria
couples who came seeking fertility through our IVF center
You may qualify if:
- Women 24-37 years old
- With good ovarian reserve
- Induction using Long agonist protocol
- unexplained infertility
You may not qualify if:
- severe male factor
- Testicular samples for ICSI
- poor ovarian reserve
- no of oocytes collected less than 4
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ahmed Saadlead
- Hawaa Fertility Centercollaborator
Study Sites (1)
Hawaa Fertility Center
Banhā, Qalyubia Governorate, 13512, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assistant professor of Obstetrics & Gynecology
Study Record Dates
First Submitted
December 1, 2019
First Posted
December 4, 2019
Study Start
June 1, 2019
Primary Completion
October 1, 2020
Study Completion
December 1, 2020
Last Updated
September 21, 2022
Record last verified: 2022-09
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- after 1 year for 2 months
after completion of the study