Reliability and Validity of the Glittre Activities of Daily Living Test in Multiple Sclerosis Patients

NCT04182269 | Completed

• 1 other identifier: Hacettepe UN
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with Multiple Sclerosis (MS) have reduced functional capacity due to clinical symptoms of the disease, resulting in decreased participation in daily living activities and reduced quality of life. Evaluation of functional capacity and activities of daily living is very important in order to determine appropriate rehabilitation programs and increase the participation of patients in daily life activities. However, although there are many scales evaluating functional capacity and activities of daily living in people with disabilities, there is no specific assessment scale specific to MS patients. Therefore, this study was planned to investigate whether the Glittre Daily Living Activities (ADL) Test, which was developed to measure functional capacity in chronic obstructive pulmonary disease, is a valid and reliable measurement tool in MS patients. For this purpose, a total of 51 participants (25 MS patients and 26 healthy participants) evaluated with Glittre ADL Test. The relationship between Glittre ADL Test and 6-minute walk test, Notthingham Extended Daily Living Activities Index, Multiple Sclerosis Quality of Life Scale, Fatigue Severity Scale, Balance Assessment Systems Test (MiniBEST Test), Extended Disability Status Scale and 5-repetition sit-to-stand test evaluated with Pearson or Spearman correlation coefficient. For the known group validity, the difference between the patient and control groups compared with the test of the difference between the two means. For reliability, test retest performed. Reliability evaluated with the intraclass correlation coefficient. Hypothesis 1: Glittre ADL Test results in MS patients and healthy subjects are different. Hypothesis 2: Glittre ADL Test is reliable in MS patients. Hypothesis 3: Glittre ADL Test is valid for evaluating functional exercise capacity in MS patients.

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis; Glittre ADL test; Functional capacity assesment

Outcome Measures

Primary Outcomes (1)

• Glittre Activities of Dailiy Living Test

  Functional exercise capacity measurement

  10 minute

Secondary Outcomes (7)

• 6 minute walk test (6MWT)

  10 minute

• Nottingham Extended Daily Living Activities Index (NGGYAI)

  10 minute

• Extended Disability Status Scale (EDSS)

  minimum 30 minute

• Fatigue Severity Scale

  10 minute

• Multiple Sclerosis Quality of Life İnstrument - 54 (MSQOL-54)

  15 minute

Study Arms (2)

Study Group

Multiple Sclerosis Patients

Other: Measurement of functional exercise capacity

Control Group

Healthy Subjects

Other: Measurement of functional exercise capacity

Interventions

Measurement of functional exercise capacity OTHER

The Glittre Activities of Daily Living (ADL) Test was used to evaluate functional exercise capacity.

Control Group; Study Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Volunteers of the patients who applied to Hacettepe University Neurology Department, diagnosed with MS by specialist physician and referred to Hacettepe University Faculty of Health Sciences Physiotherapy and Rehabilitation Department for physiotherapy and rehabilitation program were included in the study.

You may qualify if:

• Between 18-65 years
• Relapsing Remitting Multiple Sclerosis (RRMS) type MS disease.
• Extended Disability Status Scale (EDSS) score of maximum 4.5
• No attacks during the last 3 months
• The medication has not been changed in the last 6 months.
• Getting more than 24 points from the Standardized Mini Mental Test.

You may not qualify if:

• Having had any musculoskeletal surgery.
• Using a walking aid or orthosis.
• Having a neurological disease other than MS.
• Having orthopedic or rheumatological problems that will affect function.
• Having a peripheral vestibular problem.
• Having a cardiovascular and pulmonary disease.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

Related Publications (16)

• Langeskov-Christensen M, Heine M, Kwakkel G, Dalgas U. Aerobic capacity in persons with multiple sclerosis: a systematic review and meta-analysis. Sports Med. 2015 Jun;45(6):905-23. doi: 10.1007/s40279-015-0307-x.

  PMID: 25739555 BACKGROUND

• Skumlien S, Hagelund T, Bjortuft O, Ryg MS. A field test of functional status as performance of activities of daily living in COPD patients. Respir Med. 2006 Feb;100(2):316-23. doi: 10.1016/j.rmed.2005.04.022. Epub 2005 Jun 6.

  PMID: 15941658 BACKGROUND

• Savci S, Inal-Ince D, Arikan H, Guclu-Gunduz A, Cetisli-Korkmaz N, Armutlu K, Karabudak R. Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis. Disabil Rehabil. 2005 Nov 30;27(22):1365-71. doi: 10.1080/09638280500164479.

  PMID: 16372431 BACKGROUND

• Nicholl CR, Lincoln NB, Playford ED. The reliability and validity of the Nottingham Extended Activities of Daily Living Scale in patients with multiple sclerosis. Mult Scler. 2002 Oct;8(5):372-6. doi: 10.1191/1352458502ms827oa.

  PMID: 12356202 BACKGROUND

• Sahin F, Yilmaz F, Ozmaden A, Kotevoglu N, Sahin T, Kuran B. Reliability and validity of the Turkish version of the Nottingham Extended Activities of Daily Living Scale. Aging Clin Exp Res. 2008 Oct;20(5):400-5. doi: 10.1007/BF03325144.

  PMID: 19039280 BACKGROUND

• Moller AB, Bibby BM, Skjerbaek AG, Jensen E, Sorensen H, Stenager E, Dalgas U. Validity and variability of the 5-repetition sit-to-stand test in patients with multiple sclerosis. Disabil Rehabil. 2012;34(26):2251-8. doi: 10.3109/09638288.2012.683479. Epub 2012 May 22.

  PMID: 22612360 BACKGROUND

• Armutlu K, Korkmaz NC, Keser I, Sumbuloglu V, Akbiyik DI, Guney Z, Karabudak R. The validity and reliability of the Fatigue Severity Scale in Turkish multiple sclerosis patients. Int J Rehabil Res. 2007 Mar;30(1):81-5. doi: 10.1097/MRR.0b013e3280146ec4.

  PMID: 17293726 BACKGROUND

• Idiman E, Uzunel F, Ozakbas S, Yozbatiran N, Oguz M, Callioglu B, Gokce N, Bahar Z. Cross-cultural adaptation and validation of multiple sclerosis quality of life questionnaire (MSQOL-54) in a Turkish multiple sclerosis sample. J Neurol Sci. 2006 Jan 15;240(1-2):77-80. doi: 10.1016/j.jns.2005.09.009. Epub 2005 Nov 8.

  PMID: 16277993 BACKGROUND

• Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444-52. doi: 10.1212/wnl.33.11.1444.

  PMID: 6685237 BACKGROUND

• Cameron M, Mazumder R, Murchison C, King L. Mini Balance Evaluation Systems Test in people with multiple sclerosis: reflects imbalance but may not predict falls. Gait Posture. 2014;39(1):669. doi: 10.1016/j.gaitpost.2013.08.009. Epub 2013 Oct 17. No abstract available.

  PMID: 24184138 BACKGROUND

• Compston A, Coles A. Multiple sclerosis. Lancet. 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7.

  PMID: 18970977 BACKGROUND

• Mansson E, Lexell J. Performance of activities of daily living in multiple sclerosis. Disabil Rehabil. 2004 May 20;26(10):576-85. doi: 10.1080/09638280410001684587.

  PMID: 15204511 BACKGROUND

• Marrie RA, Hanwell H. General health issues in multiple sclerosis: comorbidities, secondary conditions, and health behaviors. Continuum (Minneap Minn). 2013 Aug;19(4 Multiple Sclerosis):1046-57. doi: 10.1212/01.CON.0000433284.07844.6b.

  PMID: 23917100 BACKGROUND

• Stickland MK, Butcher SJ, Marciniuk DD, Bhutani M. Assessing exercise limitation using cardiopulmonary exercise testing. Pulm Med. 2012;2012:824091. doi: 10.1155/2012/824091. Epub 2012 Nov 19.

  PMID: 23213518 BACKGROUND

• Karloh M, Araujo CL, Gulart AA, Reis CM, Steidle LJ, Mayer AF. The Glittre-ADL test reflects functional performance measured by physical activities of daily living in patients with chronic obstructive pulmonary disease. Braz J Phys Ther. 2016 Apr 8;20(3):223-30. doi: 10.1590/bjpt-rbf.2014.0155.

  PMID: 27437713 BACKGROUND

• Kaya G, Kose N, Salci Y, Armutlu K, Karakaya J, Tuncer A, Karabudak R. Reliability and validity of the glittre activities of daily living test in fully ambulatory multiple sclerosis patients. Ir J Med Sci. 2023 Oct;192(5):2379-2386. doi: 10.1007/s11845-022-03237-x. Epub 2022 Dec 1.

  PMID: 36451004 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Nezire KÖSE, Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Rana KARABUDAK, Prof.

  Hacettepe University

  STUDY CHAIR

• Meryem A TUNCER, Prof.

  Haceetepe University

  STUDY CHAIR

• Kadriye ARMUTLU, Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Yeliz SALCI, Asts. Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Jale KARAKAYA, Assoc. Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: November 26, 2019
• First Posted: December 2, 2019
• Study Start: October 1, 2018
• Primary Completion: October 15, 2019
• Study Completion: August 4, 2020
• Last Updated: February 12, 2021

Record last verified: 2021-02

Locations

TU (1)