NCT04172415

Brief Summary

To review current Emergency Department procedural sedation practices in the community hospital setting and the associated drugs used (class of anesthetic and mode of administration). The ultimate goal of this investigation is to determine the need for a new analgesic/anesthesia drug and to compare the outcomes of a new drug within the same community Emergency Department setting. In particular, this may present a future opportunity to evaluate Penthrox (methoxyflurane) as a viable alternative for procedural sedation and analgesia in Canadian Emergency Departments.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2019

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 29, 2019

Completed
23 days until next milestone

First Posted

Study publicly available on registry

November 21, 2019

Completed
9 days until next milestone

Study Start

First participant enrolled

November 30, 2019

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2020

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2020

Completed
Last Updated

November 21, 2019

Status Verified

November 1, 2019

Enrollment Period

6 months

First QC Date

October 29, 2019

Last Update Submit

November 20, 2019

Conditions

Keywords

Procedural SedationChart Review

Outcome Measures

Primary Outcomes (5)

  • Procedural Sedation

    Total number of patients requiring conscious sedation

    2 years

  • Medication Use

    The number and type of medications used during procedure

    2 years

  • Pre Procedural Assessment Findings

    ASA score, 3-3-2 Abnormality, Pre-procedure Fast, Mallampatie Class, Neck Obesity, Facial Hair

    2 years

  • Sedation Failures and Use of Rescue Medications

    Number of occurrences where sedation is inadequate for treatment and number/type of rescue medication used to achieve adequate sedation

    2 years

  • Time of Discharge

    Time of patient discharge or transfer from Emergency Department

    2 years

Secondary Outcomes (5)

  • Length of time spent in Emergency Department

    2 years

  • Duration of Procedure and Time to discharge

    2 years

  • Number of Adverse Outcomes

    2 years

  • Rate of Hospital Admission

    2 years

  • Time from Triage to initiation of procedural sedation

    2 years

Study Arms (1)

Retrospective cohort

Patients that received procedural sedation in a community Emergency Department.

Other: Retrospective cohort

Interventions

Chart Review

Retrospective cohort

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who have registered in the Welland County General Hospital Emergency Department (WHS) from the dates of January 2017 -December 2018 and require procedural sedation.

You may qualify if:

  • patients who have registered in the Welland County General Hospital Emergency Department (WHS) from the dates of January 2017-December 2018.
  • Patients who require procedural sedation in the Emergency Department

You may not qualify if:

  • \- N/A

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Niagara Health

St. Catharines, Ontario, L2S 0A9, Canada

Location

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

October 29, 2019

First Posted

November 21, 2019

Study Start

November 30, 2019

Primary Completion

June 1, 2020

Study Completion

October 1, 2020

Last Updated

November 21, 2019

Record last verified: 2019-11

Data Sharing

IPD Sharing
Will not share

Locations