Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System
Pro-MagIC
Prospective Long Term Follow-up Analysis of Exercise-induced Physiological Changes in Male Runners
1 other identifier
observational
277
1 country
1
Brief Summary
Pro-MagIC is a prospective observational study and includes participants of the Be-MaGIC-Study 2009 (n=277/NCT00933218). We aim to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 13, 2019
CompletedStudy Start
First participant enrolled
November 15, 2019
CompletedFirst Posted
Study publicly available on registry
November 18, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 5, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedSeptember 17, 2025
March 1, 2020
11 months
November 13, 2019
September 11, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Changes of right ventricular systolic function (RV-EF)
Echocardiography
10 years
Secondary Outcomes (8)
Changes in left ventricular ejection fraction (LV-EF)
10 years
Changes in left ventricular diastolic function (E/e´)
10 years
Change in cardiac markers (e.g. cardiac Troponin)
10 years
Change in inflammation markers (e.g. C-reactive Protein)
10 years
Change in microcirculation (e.g. arteriolar-to-venular ratio)
10 years
- +3 more secondary outcomes
Eligibility Criteria
Participants of the Be-MaGIC-Study (2009)
You may qualify if:
- Declaration of consent Participants must have participated in the Be-MaGIC study in 2009
- current age: 30 - 70 years
- sex: male
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Technical University of Munichlead
- Balgrist University Hospitalcollaborator
- Deutsches Herzzentrum Muenchencollaborator
Study Sites (1)
Department of Prevention, Rehabilitation and Sports Medicine, Munich, Germany
Munich, Bavaria, 80992, Germany
Related Publications (2)
Matsushima M, Bryan GT. Early induction of mouse urinary bladder ornithine decarboxylase activity by rodent vesical carcinogens. Cancer Res. 1980 Jun;40(6):1897-901.
PMID: 7371022BACKGROUNDSchoenfeld J, Schindler MJ, Haller B, Holdenrieder S, Nieman DC, Halle M, La Gerche A, Scherr J. Prospective long-term follow-up analysis of the cardiovascular system in marathon runners: study design of the Pro-MagIC study. BMJ Open Sport Exerc Med. 2020 Jul 19;6(1):e000786. doi: 10.1136/bmjsem-2020-000786. eCollection 2020.
PMID: 32704381DERIVED
Biospecimen
blood sample: whole blood, serum, plasma
MeSH Terms
Conditions
Study Officials
- STUDY DIRECTOR
Michael Schindler, MD
Department of Prevention, Rehabilitation and Sports Medicine, Munich, Germany
- PRINCIPAL INVESTIGATOR
Johannes Scherr, MD
University Hospital Balgrist, University Zurich, Switzerland
- STUDY DIRECTOR
Martin Halle, MD
Department of Prevention, Rehabilitation and Sports Medicine, Munich, Germany
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr. med. Johannes Scherr
Study Record Dates
First Submitted
November 13, 2019
First Posted
November 18, 2019
Study Start
November 15, 2019
Primary Completion
October 5, 2020
Study Completion
June 30, 2021
Last Updated
September 17, 2025
Record last verified: 2020-03
Data Sharing
- IPD Sharing
- Will not share