Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

NCT04166851 | Completed Results

• 1 other identifier: 00008650
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to examine the utility of neuroimaging technique to evaluate pre-exposure prophylaxis (PrEP) promotion messages for men who have sex with men (MSM) at risk of HIV in Baltimore.

Conditions

HIV/AIDS

Keywords

Pre-exposure prophylaxis; Health Promotion; HIV/AIDS primary prevention; men who have sex with men; Neuroimaging

Outcome Measures

Primary Outcomes (1)

• Change of Willingness to Take PrEP

  Questions on willingness to take PrEP. Participants will be asked, "Suppose that PrEP is at least 90% effective in preventing HIV when taken daily. How likely would you be to take PrEP if it were available for free?" with responses ranging from "Extremely unlikely-1," "Somewhat unlikely-2," "Somewhat likely-3," "Extremely likely-4." The mean of the changes between baseline and after participants reviewed the messages was calculated.

  baseline, 30 days post baseline

Study Arms (2)

Open contest messages

EXPERIMENTAL

Participants will view the top PrEP-promotion messages developed via an open contest.

Behavioral: PrEP campaign messages developed via open contest

Social marketing messages

ACTIVE COMPARATOR

Participants will view the PrEP-promotion messages developed via social marketing.

Behavioral: PrEP campaign messages developed via social marketing approach

Interventions

PrEP campaign messages developed via open contest BEHAVIORAL

PrEP campaign messages will be developed via an open contest in Baltimore.

Open contest messages

PrEP campaign messages developed via social marketing approach BEHAVIORAL

PrEP campaign messages developed with a traditional social marketing approach.

Social marketing messages

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years and older
• Biological male sex at birth
• Sexually active with men in the past 6 months
• Never taken PrEP
• HIV negative
• Reside in Baltimore City or surrounding counties
• Meet one of the criteria for being an appropriate PrEP candidate (i.e. in a relationship with a partner not known to be HIV-negative; are in a nonmonogamous relationship; have had any condomless anal sex with a casual male partner regardless of status in the prior 6 months; or had a positive sexual transmitted infection (STI) diagnosis within the prior 6 months).

You may not qualify if:

• \- Participated in open contest

Sponsors & Collaborators

• Johns Hopkins Bloomberg School of Public Health: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

Johns Hopkins Bloomberg School of Public Health

Baltimore, Maryland, 21205, United States

Location

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome; Homosexuality

Condition Hierarchy (Ancestors)

HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Sexuality; Sexual Behavior; Behavior

Results Point of Contact

• Title: Cui Yang
• Organization: Rutgers School of Public Health

cui.yang@rutgers.edu

1-732-235-9754

Study Officials

• Cui Yang, PhD

  Johns Hopkins Bloomberg School of Public Health

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 23, 2019
• First Posted: November 18, 2019
• Study Start: November 15, 2019
• Primary Completion: October 1, 2023
• Study Completion: October 30, 2023
• Last Updated: October 22, 2024
• Results First Posted: October 22, 2024

Record last verified: 2024-09

Locations

US (1)