Single Cell Sequencing Analysis of Thymoma

NCT04162691 | Unknown DMC

• 1 other identifier: SCS-001
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.

Conditions

Thymoma

Outcome Measures

Primary Outcomes (1)

• Determination of cell population from thymoma

  The genes expression and the cell population

  through study completion, an average of 1 year

Study Arms (2)

Malignant thymoma

Diagnostic Test: Tissue

Benign thymoma

Diagnostic Test: Tissue

Interventions

Tissue DIAGNOSTIC_TEST

Four 4-5 mm tissues of the thymoma

Benign thymoma; Malignant thymoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to the clinic for investigation of a suspected thymoma condition

You may qualify if:

• Patients diagnosed with thymoma
• Ability to provide written consent and comply with the protocol
• At least 18 years of age

You may not qualify if:

• Patients undergoing thymoma treatment
• Patients with previous malignancy
• Known HIV positive status.
• Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.

Sponsors & Collaborators

• Zhejiang Cancer Hospital: lead

Study Sites (1)

An Zhao

Hangzhou, 310022, China

RECRUITING

MeSH Terms

Conditions

Thymoma

Interventions

Histocompatibility Testing

Condition Hierarchy (Ancestors)

Neoplasms, Complex and Mixed; Neoplasms by Histologic Type; Neoplasms; Thymus Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lymphatic Diseases; Hemic and Lymphatic Diseases

Intervention Hierarchy (Ancestors)

Immunologic Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Immunologic Techniques

Central Study Contacts

An ZHAO, MD, PHD

CONTACT

8688122413; zhaoan@zjcc.org.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 6, 2019
• First Posted: November 14, 2019
• Study Start: June 6, 2020
• Primary Completion: June 1, 2021
• Study Completion: December 31, 2023
• Last Updated: January 13, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)