NCT04160689

Brief Summary

The substitution of a tooth with a fixture often induces undesired morphological changes, resulting in a deterioration of the aesthetic appearance. The purpose of this study is to compare the soft tissue behavior next to two different implant connections: 5° (group 1) and 35° hexed (group 2), conical, internal with switching platform design after 12 months of functional provisionalization

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
104

participants targeted

Target at P50-P75 for phase_4

Timeline
Completed

Started Nov 2018

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2018

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2019

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

November 9, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 13, 2019

Completed
Last Updated

November 14, 2019

Status Verified

November 1, 2019

Enrollment Period

1 year

First QC Date

November 9, 2019

Last Update Submit

November 12, 2019

Conditions

Outcome Measures

Primary Outcomes (2)

  • height of the peri-implant mucosa (MH)

    This measurement (MH) corresponds to the depth of the implant referred to the most coronal point of the buccal mucosa measured according to the main implant axis digitally calculated by 3D software Gom.

    after 12 months

  • The width (MT) of the peri-implant mucosa

    was calculated from the vestibular shoulder of the analogue to the external mucosa point perpendicular to the implant major axis digitally calculated by 3D software Gom.

    12 months

Study Arms (2)

Group 1

ACTIVE COMPARATOR

Anyridge (Mega'Gen, Korea) 5° conical internal hexed connection

Biological: implantology

Group 2

ACTIVE COMPARATOR

Core (Bioimplant, Italy) 35° conical internal hexed connection (screw-vent style)

Biological: implantology

Interventions

implantologyBIOLOGICAL

placing of implant

Group 1Group 2

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Missing teeth
  • good oral hygiene
  • good systemic health

You may not qualify if:

  • lactation
  • pregnancy
  • heavy smoking (more than 20 cigarettes/day)
  • severe medical conditions that could affect periodontal health and peri-implant tissue response
  • use of drugs correlated to periodontal hypertrophy
  • bone volume that required bone augmentation procedures before implant placement as well as soft tissue graft or any kind of peri-implant tissue engineering

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Insubria

Varese, Italy

Location

Related Publications (1)

  • Farronato D, Pasini PM, Manfredini M, Scognamiglio C, Orsina AA, Farronato M. Influence of the implant-abutment connection on the ratio between height and thickness of tissues at the buccal zenith: a randomized controlled trial on 188 implants placed in 104 patients. BMC Oral Health. 2020 Feb 17;20(1):53. doi: 10.1186/s12903-020-1037-5.

MeSH Terms

Conditions

Bone Diseases, MetabolicAlveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesBone ResorptionPeriodontal AtrophyPeriodontal DiseasesMouth DiseasesStomatognathic Diseases

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 9, 2019

First Posted

November 13, 2019

Study Start

November 1, 2018

Primary Completion

November 1, 2019

Study Completion

November 1, 2019

Last Updated

November 14, 2019

Record last verified: 2019-11

Locations