NCT04160572

Brief Summary

This study will recruit 60 night shift workers with shift work disorder. They will be invited to wear actigraphy for 3 weeks. In the first week the participants will sleep at the time they used to, and their chronotype will be determined by actigraphy and Munich Chronotype Questionnaire. In the second week the participants will be randomly assigned to morning sleep or evening sleep time, and will change to the other in the third week. We will compare sleepiness, sleep quality, daytime vigilance score changes using mixed method ANOVA. We will also examine the interaction effect of chronotype and sleep schedule on sleep-related outcome.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Dec 2019

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 8, 2019

Completed
5 days until next milestone

First Posted

Study publicly available on registry

November 13, 2019

Completed
1 month until next milestone

Study Start

First participant enrolled

December 17, 2019

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 23, 2020

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 27, 2021

Completed
Last Updated

July 30, 2021

Status Verified

July 1, 2021

Enrollment Period

1 year

First QC Date

November 8, 2019

Last Update Submit

July 28, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Sleep quality

    Pittsburgh sleep quality index (PSQI), range from 0 (better) to 21 (worse)

    Change from baseline score at the second and third week.

Secondary Outcomes (2)

  • Daytime sleepiness

    Change from baseline score at the start and end of each night shift.

  • Alertness

    Change from baseline score at the start and end of each night shift.

Study Arms (2)

Morning-evening sleep schedule

EXPERIMENTAL
Behavioral: Morning sleep scheduleBehavioral: Evening sleep schedule

Evening-morning sleep schedule

ACTIVE COMPARATOR
Behavioral: Morning sleep scheduleBehavioral: Evening sleep schedule

Interventions

sleep right after night shifts

Evening-morning sleep scheduleMorning-evening sleep schedule

sleep before night shifts

Evening-morning sleep scheduleMorning-evening sleep schedule

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Shift work disorder

You may not qualify if:

  • Neuromuscular disorder
  • Taking hypnotics
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

China Medical University Hospital

Taichung, 404332, Taiwan

Location

Related Publications (1)

  • Cheng WJ, Hang LW, Kubo T, Vanttola P, Huang SC. Impact of sleep timing on attention, sleepiness, and sleep quality among real-life night shift workers with shift work disorder: a cross-over clinical trial. Sleep. 2022 Apr 11;45(4):zsac034. doi: 10.1093/sleep/zsac034.

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Physician

Study Record Dates

First Submitted

November 8, 2019

First Posted

November 13, 2019

Study Start

December 17, 2019

Primary Completion

December 23, 2020

Study Completion

July 27, 2021

Last Updated

July 30, 2021

Record last verified: 2021-07

Data Sharing

IPD Sharing
Will not share

Locations