NCT04154839|Unknown
Epidemiological Survey and Genetic Analysis of AD Patients in Hong Kong
Pilot Study: Epidemiological Survey and Genetic Analysis of Patients With Atopic Dermatitis in Hong Kong
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Pilot Study: Epidemiological Survey and Genetic Analysis of Patients With Atopic Dermatitis in Hong Kong
Sponsor study identifier
observational
450
1 country
1
Study Start
July 12, 2019
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Study Completion
June 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
This is a joint research study between The Hong Kong Polytechnic University (PolyU) and The University of Hong Kong (HKU) as titled above. In view of the increasing prevalence of atopic dermatitis (AD), the lack of complete epidemiology data on childhood and adult AD in Hong Kong and the lack of complete understanding on the genetic and environmental factors associated with it, the purpose of this study to carry out an epidemiology and genetic study that targets AD patients within the local Hong Kong population. The investigators will search for new AD-associated genetic variants that are related to the local population and believe that the genetic profiles that arise from this project will form an important basis for the future management and treatment of AD, such as disease-risk screening strategy and therapeutic target development.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 12, 2019
Actual (reported)October 29, 2019
Actual (reported)November 7, 2019
Actual (reported)December 31, 2021
Actual (reported)June 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Significant SNPs
The significant single nucleotide polymorphisms (SNPs) between control group and different AD case subgroups (different age of onset, different AD severity, different relapsing status), Cochran-Armitage trend test will be used to assess statistical significance of the association with each SNP, and Mantel-Haenszel method for two 2 × 2 allele frequency tables will be used to assess association of SNPs on chromosome X within male and female subjects.
through study completion, an average of 1 year
Number of subjects in atopic dermatitis group 0 - \< 6 years : 50 subjects 6 - \<12 years : 50 subjects 12 - \<18 years : 50 subjects Adult (\>= 18 years) : 150 subjects Total no. of cases: 300 cases
\>= 40 yrs : 150 subjects
For AD cases: Chinese-Han AD subjects who was born in Hong Kong For Control: Chinese-Han subjects who was born in Hong Kong aged more or equal to 40 Years
Department of Medicine
Central, Hong Kong
Blood sample in K2EDTA and SST tubes and/or buccal swab
Mandy Chan, MBBS
The University of Hong Kong
First Submitted
October 29, 2019
First Posted
November 7, 2019
Study Start
July 12, 2019
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)The Role of Bathing Additives in the Treatment of Pediatric Atopic Dermatitis
Contact the study team to confirm eligibility.
Study Completion
June 30, 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 5, 2022
Record last verified: 2022-05
No plan to share individual participant data
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Source: ClinicalTrials.gov.
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