Adrenaline During Resuscitation From Pulseless Electrical Activity
1 other identifier
observational
280
2 countries
2
Brief Summary
This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2019
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 20, 2019
CompletedFirst Submitted
Initial submission to the registry
October 18, 2019
CompletedFirst Posted
Study publicly available on registry
November 4, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
May 15, 2023
CompletedSeptember 5, 2023
September 1, 2023
3.8 years
October 18, 2019
September 1, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
QRS frequency
Measurement of RR intervals in milliseconds.
Every 3 minutes from start till end of cardiopulmonary resuscitation
QRS width
Measurement of the width of QRS complexes in milliseconds
Every 3 minutes from start till end of cardiopulmonary resuscitation
Changes of clinical states
changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest.
Every 3 minutes from start till end of cardiopulmonary resuscitation
Study Arms (1)
Patients with primary PEA.
Patients at St. Olavs hospital who suffer cardiac arrest and pulseless electrical activity (PEA) as primary rhythm during 2018-2021. 120 episodes from St. Olavs hospital were collected previously (2010-2013). In addition 200 cases will be available from the hospital of The University of Pennsylvania, Philadelphia, USA.
Eligibility Criteria
The population will consist of patients suffering cardiac arrest while being hospitalized at St. Olavs hospital.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- St. Olavs Hospitallead
- Norwegian University of Science and Technologycollaborator
- University of Pennsylvaniacollaborator
Study Sites (2)
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
St Olavs Hospital
Trondheim, Norway
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Eirik Skogvoll, md prof
St. Olavs Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 18, 2019
First Posted
November 4, 2019
Study Start
March 20, 2019
Primary Completion
January 1, 2023
Study Completion
May 15, 2023
Last Updated
September 5, 2023
Record last verified: 2023-09
Data Sharing
- IPD Sharing
- Will not share