Evaluation of the Remineralizing and Antibacterial Effect of Natural Versus Synthetic Materials on Deep Carious Dentin
1 other identifier
interventional
80
1 country
1
Brief Summary
The present study will be performed to evaluate:
- 1.The remineralizing effect of natural materials versus synthetic materials on deep carious dentin after selective caries removal.
- 2.The antibacterial effect of natural materials versus synthetic materials on deep carious dentin.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2019
CompletedFirst Submitted
Initial submission to the registry
October 19, 2019
CompletedFirst Posted
Study publicly available on registry
October 30, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 20, 2020
CompletedJanuary 13, 2021
January 1, 2021
12 months
October 19, 2019
January 11, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evaluation of the Remineralizing and Antibacterial Effect of Natural Versus Synthetic Materials on Deep Carious Dentin
antibacterial effect will be evaluated by bacterial count at base line and after three months reminerliazation effect will be evaluated by radiographes
antibacterial and reminerlizing effect will be evaluated after three monthes
Study Arms (4)
negative control
NO INTERVENTIONrestoration will applied without any treatment
hesperidine
EXPERIMENTALhesperidine will be applied for remaining caries then restoration will be applied
propolis
EXPERIMENTALpropolis will be applied for remaining caries then restoration will be applied
silver diamine fluoride
EXPERIMENTALsilver diamine fluoride will be applied for remaining caries then restoration will be applied
Interventions
used for antibacterial and reminerlization assesment
Eligibility Criteria
You may qualify if:
- Subject must have active deep carious lesion.
- clinical and radiographic examinations of carious lesions.
You may not qualify if:
- Teeth with pulpal involvement
- Teeth with abscess
- Teeth with pain or swelling
- Teeth with developmental disorders
- Teeth with adjacent soft tissue lesions
- patients with systemic illness will be excluded
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Alazher university
Cairo, Nasr City, 11651, Egypt
Related Publications (1)
Anani H, Elasser D, Niazy M, Jamil W, Elsharkawy D. Evaluation of the remineralization and antibacterial effect of natural versus synthetic materials on deep carious dentin: A randomized controlled trial. Dent Med Probl. 2023 Jan-Mar;60(1):87-97. doi: 10.17219/dmp/147075.
PMID: 37023336DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Doaa Elsharkawy,Assistant Professor of operative department
Study Record Dates
First Submitted
October 19, 2019
First Posted
October 30, 2019
Study Start
January 1, 2019
Primary Completion
December 30, 2019
Study Completion
July 20, 2020
Last Updated
January 13, 2021
Record last verified: 2021-01
Data Sharing
- IPD Sharing
- Will not share