The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

NCT04144114 | Completed

• 1 other identifier: Pro18
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL). To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway. To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Conditions

Amino Acids

Keywords

Amino Acids; Intramuscular Anabolic Signaling; Endocrine Response; Resistance Training

Outcome Measures

Primary Outcomes (3)

• Amino acid absorption

  To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL)

  4 weeks

• mTORC1 pathway

  To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway

  4 weeks

• Endocrine markers

  To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

  4 weeks

Study Arms (3)

Whey + ProHydrolase®

EXPERIMENTAL

Subjects received 250mg of ProHydrolase® along with 25g of whey protein mixed in a drink every visit for 4 weeks

Dietary Supplement: ProHydrolase®

Whey

ACTIVE COMPARATOR

Subjects received 25g whey protein in a drink every visit for 4 weeks

Dietary Supplement: Whey protein

Placebo

PLACEBO COMPARATOR

Subjects received 25g maltodextrin in a drink every visit for 4 weeks

Dietary Supplement: Placebo

Interventions

ProHydrolase® DIETARY_SUPPLEMENT

Subjects received 250mg of ProHydrolase® with 25g whey protein mixed together in a drink

Whey + ProHydrolase®

Whey protein DIETARY_SUPPLEMENT

Subjects received 25g of whey protein powder mixed to together in a drink

Whey

Placebo DIETARY_SUPPLEMENT

Placebo

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• At least one-year of resistance training experience
• Free of any physical limitations (determined by health and activity questionnaire).
• Between the ages of 18 and 35.
• Ability to leg press a weight equivalent to 1.5 times their body mass

You may not qualify if:

• Inability to perform physical exercise (determined by health and activity questionnaire)
• Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).
• Physical injury preventing the athlete from participating in offseason training
• Any chronic illness that causes continuous medical care

Sponsors & Collaborators

• Deerland Enzymes: lead
• Lipscomb University: collaborator

Study Sites (1)

Lipscomb University

Nashville, Tennessee, 37204, United States

Location

MeSH Terms

Interventions

Whey Proteins

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 28, 2019
• First Posted: October 30, 2019
• Study Start: August 1, 2018
• Primary Completion: December 7, 2018
• Study Completion: December 7, 2018
• Last Updated: October 30, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)