Human Visual and Vestibular Motion Perception Study

NCT04142697 | Recruiting

• 2 other identifiers: 3911R01DC013580
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose this study is to measure sensitivity to visual and vestibular or balance motion. It is hoped that the results may help researchers better understand how aging and disease affect motion perception.

Conditions

Vestibular Disease

Outcome Measures

Primary Outcomes (1)

• Change in Mean Heading perception

  Heading perception will be measured using two alternative forced choice and magnitude estimation procedures and reported in degrees. It is measured in degrees of azimuth with positive to the right and negative to the left of straight ahead (defined as 0 degrees).

  Baseline to 1 week

Secondary Outcomes (1)

• Change in Mean Dizziness Handicap Inventory (DHI)

  Baseline to 1 week

Study Arms (2)

Healthy subjects

ACTIVE COMPARATOR

Behavioral: Heading direction adaptation

Vestibular Disease patients

ACTIVE COMPARATOR

Behavioral: Heading direction adaptation

Interventions

Heading direction adaptation BEHAVIORAL

Will adapt subject's perceived heading direction using exposure to visual environments that include rotation and situations where visual and inertial heading direction are systematically offset.

Healthy subjects; Vestibular Disease patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects:
• general good health
• Vestibular Disease patients:
• general good health
• specific unilateral or bilateral vestibular loss

You may not qualify if:

• Healthy subjects:
• subjects who are institutionalized or otherwise not self-sufficient.
• enduring sequelae due to diseases of the nervous system, eyes, ears, head and neck, and limbs, except for changes commensurate with normal aging (e.g. presbyacusic hearing loss, mild cataract, etc.).
• abnormal cognitive function, which if in question can be determined as a score of \<27 on the Mini-Mental State test.
• corrected visual acuity worse than 20/20 up to age 65, worse than 20/40 if \>65
• abnormal binocular stereo-acuity or visual fields.
• any defects in cranial nerve, oculomotor, cerebellar/coordination, and somatosensory functions.
• any abnormal oculomotor and vestibular function (caloric tests)
• Vestibular Disease patients:
• Inability to perform the study tasks due to sensory, motor, or postural limitations

Sponsors & Collaborators

• University of Rochester: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (1)

University of Rochester Medical Center

Rochester, New York, 14618, United States

RECRUITING

MeSH Terms

Conditions

Vestibular Diseases

Condition Hierarchy (Ancestors)

Labyrinth Diseases; Ear Diseases; Otorhinolaryngologic Diseases

Central Study Contacts

Cesar Arduino

CONTACT

585-273-2043; Cesar_Arduino@urmc.rochester.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: October 21, 2019
• First Posted: October 29, 2019
• Study Start: September 15, 2020
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2027
• Last Updated: January 12, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

US (1)