Shrunken Pore Syndrome: a Retrospective, Single Center, Cohort Study
Shrunken Pore Syndrome's Effect on Mortality in Elective Cardiac Surgery
1 other identifier
observational
4,719
1 country
1
Brief Summary
To study the impact a difference in renal clearance of small and large molecules has on long-term survival.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
January 10, 2019
CompletedFirst Submitted
Initial submission to the registry
October 24, 2019
CompletedFirst Posted
Study publicly available on registry
October 28, 2019
CompletedSeptember 21, 2021
September 1, 2021
6 years
October 24, 2019
September 14, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mortality during follow up
All cause mortality at follow up
1 January 2010 - 1 January 2019
Interventions
eGFR Cystatin C ≤ 60% of eGFR Creatinine
Eligibility Criteria
Skåne University Hospital in Lund is a tertiary care hospital that is the sole provider of cardiac surgery to the Southern part of Sweden, comprising 1 500 000 people.
You may qualify if:
- Elective CABG and/or sAVR at the department of Cardiothoracic Surgery, Skåne University Hospital in Lund, Sweden between 1 January 2010 and 31 December 2015.
You may not qualify if:
- Emergency operation
- Redo operation
- Preoperatively missing cystatin C or creatinine
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Henrik Bjurstenlead
Study Sites (1)
Skåne University Hospital
Lund, Skåne County, 22241, Sweden
Related Publications (4)
Dardashti A, Nozohoor S, Grubb A, Bjursten H. Shrunken Pore Syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting. Scand J Clin Lab Invest. 2016;76(1):74-81. doi: 10.3109/00365513.2015.1099724.
PMID: 26647957BACKGROUNDGrubb A, Lindstrom V, Jonsson M, Back SE, Ahlund T, Rippe B, Christensson A. Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: 'Shrunken pore syndrome'. Scand J Clin Lab Invest. 2015 Jul;75(4):333-40. doi: 10.3109/00365513.2015.1025427.
PMID: 25919022BACKGROUNDHerou E, Dardashti A, Nozohoor S, Zindovic I, Ederoth P, Grubb A, Bjursten H. The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFRcystatin C/eGFRcreatinine-ratio. Scand J Clin Lab Invest. 2019 May;79(3):167-173. doi: 10.1080/00365513.2019.1576101. Epub 2019 Feb 15.
PMID: 30767571RESULTHerou E, Grubb A, Dardashti A, Nozohoor S, Zindovic I, Ederoth P, Bjursten H. Reduced renal elimination of larger molecules is a strong predictor for mortality. Sci Rep. 2022 Oct 20;12(1):17517. doi: 10.1038/s41598-022-22433-4.
PMID: 36266435DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Henrik Bjursten, MD PhD
Region Skåne
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assoc. Prof
Study Record Dates
First Submitted
October 24, 2019
First Posted
October 28, 2019
Study Start
January 1, 2010
Primary Completion
December 30, 2015
Study Completion
January 10, 2019
Last Updated
September 21, 2021
Record last verified: 2021-09
Data Sharing
- IPD Sharing
- Will not share