NCT04138784

Brief Summary

Knee osteoarthritis is a common condition characterized by pain and functional disability in older people. Prevalence increases with age and is more frequent in older women. The aim of this study was to assess the effects of an 8-weeks individualized comprehensive rehabilitation program with elastic bands on pain and functional disability in chronic knee osteoarthritis.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
38

participants targeted

Target at P25-P50 for not_applicable knee-osteoarthritis

Timeline
Completed

Started Dec 2019

Shorter than P25 for not_applicable knee-osteoarthritis

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 23, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 25, 2019

Completed
1 month until next milestone

Study Start

First participant enrolled

December 1, 2019

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2020

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2020

Completed
Last Updated

November 13, 2019

Status Verified

November 1, 2019

Enrollment Period

2 months

First QC Date

October 23, 2019

Last Update Submit

November 11, 2019

Conditions

Outcome Measures

Primary Outcomes (4)

  • Changes in Functionality

    Changes in Functionality is going to be assessed by the Western Ontario and McMaster Universities (WOMAC). Scores range from 0 to 96, with higher scores indicating greater disease severity.

    Baseline, 8 weeks, 3 months

  • Changes in Physical Performance

    Changes in Physical Performance is going to be assessed using the Stairs Climbing Test. This test assesses the ability to ascend and descend a flight of stairs, as well as lower extremity strength, power, and balance.

    Baseline, 8 weeks, 3 months

  • Changes in Physical Performance

    Changes in Physical Performance is going to be assessed by The Timed up ad go. It involves a person standing from a 46-cm-high chair, walking 3 m, turning, walking back to the chair and sitting down.

    Baseline, 8 weeks, 3 months

  • Changes in Perceived Health Status

    Changes in Perceived Health Status is going to be assessed by the EuroQol-5D.It contains two sections, a descriptive section and a valuation section. The descriptive section is a health status classification instrument with the following five dimensions: mobility; self-care; usual activities; pain/discomfort; and anxiety/depression. In the second section, respondents are asked to value their overall health status on a visual analogue scale ranging from 0 (defined as the worst imaginable health state) to 100 (defined as the best imaginable health state)

    Baseline, 8 weeks, 3 months

Study Arms (2)

Comprehensive Rehabilitation program

EXPERIMENTAL

19 women will be recruited in order to the inclusion criteria for the study and they will receive an 8-weeks individualized comprehensive rehabilitation program administered once a day.

Other: Individualized comprehensive rehabilitation program

Aquatic training

EXPERIMENTAL

18 women will be recruited in order to the inclusion criteria for the study and they will receive an 8-weeks hydrotherapy intervention once a day.

Other: Aquatic training

Interventions

The program general contents were pain education, joint protection techniques, general care lifestyle habits, which were complemented by a problem-based session. The program plan was designed to fit patients' goals, priorities, and lifestyles after an initial interview.

Comprehensive Rehabilitation program

Patients received a 45 min-water exercise program which included balance and proprioception activities, isometric exercise, flexibility exercises, core stabilization exercises and aerobic/endurance exercises. All sessions were developed in groups and addressed by a qualified professional.

Aquatic training

Eligibility Criteria

Age65 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Diagnosis of primary symptomatic KOA according to the criteria of the American College of Rheumatology
  • Women aged older than 65 years
  • Pain predominantly over the last 3 months
  • Kellgren and Lawrence score ≥2.

You may not qualify if:

  • Ankle, hip or foot severe disorders
  • Chronic back pain
  • Alzheimer's disease, Parkinson's disease, motor neuron disorders.
  • Diabetes mellitus
  • Cardiac or respiratory insufficiency
  • Inability to understand the procedure

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Lopez LL, Benitez PO, Lopez JC, Martos IC, Torres JR, Santiago MG, Valenza MC. Effectiveness of an individualized comprehensive rehabilitation program in women with chronic knee osteoarthritis: a randomized controlled trial. Menopause. 2022 Jun 1;29(6):687-692. doi: 10.1097/GME.0000000000001959.

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Central Study Contacts

Marie Carmen Valenza, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant profressor

Study Record Dates

First Submitted

October 23, 2019

First Posted

October 25, 2019

Study Start

December 1, 2019

Primary Completion

February 1, 2020

Study Completion

March 1, 2020

Last Updated

November 13, 2019

Record last verified: 2019-11