Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)

NCT04135703 | Completed Results DMC

• 2 other identifiers: 2019B0287UH3DA050174
• Study Type: interventional
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Homeless youth have a much higher rate of substance use than non-homeless peers with evidence suggesting that homeless youth have the highest rates of opioid use among youth subgroups in the country (Brands et al., 2005); heroin using homeless youth also appear to have the highest rates of IV drug use and HIV (Rhoades et al., 2014). Given the high rates of opioid use, exposure to violence, mental and physical health challenges, and high rates of mortality in homeless youth, it is surprising that no study to date utilizes a randomized controlled design to test prevention of opioid and other drug use among this vulnerable population. Resolution of youth homelessness through housing and prevention services, often referred to as "Housing First", as proposed in the current study, has great potential to reduce the likelihood for the development of an opioid use disorder as well as other problem behaviors associated with living on the streets. However, only 20-30% of homeless youth samples report ever having stayed at a crisis shelter, 9% report having ever accessed mental health services, and 15% report ever having received substance use treatment (Ray, 2006) indicating a need to reach and engage youth in services that are feasible and acceptable. This study will provide essential information for researchers and providers on the efficacy of housing + opioid and related risk prevention services in an RCT on opioid use, how moderators affect the response, and mechanisms underlying change.

Conditions

Substance Use

Outcome Measures

Primary Outcomes (1)

• Frequency (% Days) of Opioid Use in Prior 3 Months

  frequency (% days in prior 90) of opioid use is measured at baseline, 3, 6, 9 and 12 months post-baseline

  12 months

Study Arms (2)

Risk Prevention Services +Housing

EXPERIMENTAL

Opioid and related prevention services including Strengths-Based Outreach and Advocacy (SBOA), MI, HIV risk and suicide prevention (CTSP) as well as rental and utility assistance for 6 months.

Behavioral: Risk Prevention Services + Housing

Risk Prevention Services Only

EXPERIMENTAL

Opioid and related prevention services including Strengths-Based Outreach and Advocacy (SBOA), MI, HIV risk and suicide prevention (CTSP).

Behavioral: Risk Prevention Services Only

Interventions

Risk Prevention Services + Housing BEHAVIORAL

opioid and related prevention services in addition to 6 months of rental assistance

Risk Prevention Services +Housing

Risk Prevention Services Only BEHAVIORAL

opioid and related prevention services for 6 months

Risk Prevention Services Only

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• ages of 18 to 24 years
• meets McKinney-Vento definition of homeless
• fails to meet DSM 5 criteria for Opioid Use Disorder as assessed by the SCID

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University

Columbus, Ohio, 43210, United States

Location

Related Publications (4)

• Kuklinski MR, Gibbons BJ, Bowser DM, McCollister KE, Smart R, Dunlap LJ, Shenkar E, Bonar EE, Boomer T, Campbell M, Fiellin LE, Hutton DW, Rao V, Saldana L, Su K, Walton MA, Yilmazer T. Investing in Interventions to Prevent Opioid Use Disorder in Adolescents and Young Adults: Start-up Costs from NIDA's HEAL Prevention Initiative. Prev Sci. 2025 Nov;26(7):1045-1055. doi: 10.1007/s11121-025-01835-6. Epub 2025 Oct 14.

  PMID: 41085955 DERIVED

• Ahrens K, Blackburn N, Aalsma M, Haggerty K, Kelleher K, Knight DK, Joseph E, Mulford C, Ryle T, Tolou-Shams M. Prevention of Opioid Use and Disorder Among Youth Involved in the Legal System: Innovation and Implementation of Four Studies Funded by the NIDA HEAL Initiative. Prev Sci. 2023 Oct;24(Suppl 1):99-110. doi: 10.1007/s11121-023-01566-6. Epub 2023 Jul 1.

  PMID: 37393415 DERIVED

• Chavez L, Kelleher K, Bunger A, Brackenoff B, Famelia R, Ford J, Feng X, Mallory A, Martin J, Sheftall A, Walsh L, Yilmazer T, Slesnick N. Housing First Combined with Suicide Treatment Education and Prevention (HOME + STEP): study protocol for a randomized controlled trial. BMC Public Health. 2021 Jun 12;21(1):1128. doi: 10.1186/s12889-021-11133-9.

  PMID: 34118916 DERIVED

• Slesnick N, Chavez L, Bunger A, Famelia R, Ford J, Feng X, Higgins S, Holowacz E, Jaderlund S, Luthy E, Mallory A, Martin J, Walsh L, Yilmazer T, Kelleher K. Housing, opportunities, motivation and engagement (HOME) for homeless youth at-risk for opioid use disorder: study protocol for a randomized controlled trial. Addict Sci Clin Pract. 2021 May 12;16(1):30. doi: 10.1186/s13722-021-00237-7.

  PMID: 33980315 DERIVED

MeSH Terms

Conditions

Substance-Related Disorders

Interventions

Housing

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Non-Medical Public and Private Facilities; Residence Characteristics; Demography; Population Characteristics; Environment, Controlled; Environment; Environment and Public Health; Epidemiologic Measurements; Public Health

Results Point of Contact

• Title: Natasha Slesnick
• Organization: The Oho State University

slesnick.5@osu.edu

6142478469

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 20, 2019
• First Posted: October 23, 2019
• Study Start: June 23, 2020
• Primary Completion: May 14, 2024
• Study Completion: May 14, 2024
• Last Updated: September 15, 2025
• Results First Posted: September 15, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)