The Relationship Between NK Cell and Graves' Disease
Mechanism of NK Cell Disfunction in Graves' Disease
1 other identifier
observational
200
1 country
1
Brief Summary
Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 15, 2018
CompletedFirst Submitted
Initial submission to the registry
January 3, 2019
CompletedFirst Posted
Study publicly available on registry
October 22, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2022
CompletedApril 14, 2021
April 1, 2021
3.7 years
January 3, 2019
April 12, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The number and function of NK cells changes of hyperthyroidism
Flow cytometry used to measure the related changes of NK cells in hyperthyroidism
measured after 2 years of follow-up
Secondary Outcomes (1)
Changes in serum levels
measured after 2 years of follow-up
Study Arms (2)
New untreated GD patients
Before treatment and application of anti-thyroid drugs (methimazole) or radioactive iodine treatment
Healthy control
No thyroid related diseases and other immune diseases
Eligibility Criteria
Adults aged of 18 to 75 years old
You may qualify if:
- New GD patients without any treatment
- Aged of 18 to 75 years old
You may not qualify if:
- Pregnant or lactating woman;
- Known autoimmune disease;
- Receiving psychotropic or hormonal drugs;
- Taking drugs that affect the body's immune function;
- Obviously poor compliance.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shandong Provincial Hospital
Jinan, Shandong, 250021, China
Biospecimen
serum，whole blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Haiqing Zhang
Shandong Provincial Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 6 Months
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- professor
Study Record Dates
First Submitted
January 3, 2019
First Posted
October 22, 2019
Study Start
October 15, 2018
Primary Completion
June 30, 2022
Study Completion
June 30, 2022
Last Updated
April 14, 2021
Record last verified: 2021-04