NCT04131855

Brief Summary

The aim of the study is to investigate the role of pumice prophylaxis in the self etch primer method on clinical bond strengths. The relevance is that removal of the pumicing step in the SEP method could potentially save time \& cost for clinicians, and decrease discomfort for patients if it does not affect bond strengths. The null hypothesis that will be tested is that pumice prophylaxis does not affect orthodontic bracket failure rates when used with the self etch primer. The alternative hypothesis is that there are less orthodontic bracket failures in the pumiced group while using the self etch primer.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2019

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 17, 2019

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 18, 2019

Completed
14 days until next milestone

Study Start

First participant enrolled

November 1, 2019

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2021

Completed
28 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2021

Completed
Last Updated

October 21, 2019

Status Verified

October 1, 2019

Enrollment Period

1.3 years

First QC Date

October 17, 2019

Last Update Submit

October 17, 2019

Conditions

Keywords

self etch primerspumiceorthodontic bracket failure

Outcome Measures

Primary Outcomes (1)

  • To compare the bond failure rates between pumiced and non-pumiced teeth.

    Done by calculating and comparing the percentage of bracket breakages between the pumiced and non-pumiced quadrants.

    Data on bond failure will be collected at 1 month after placement of the 19x25 SS wire.

Secondary Outcomes (2)

  • To compare the bracket breakage rates between anterior and posterior teeth.

    Data on bond failure will be collected at 1 month after placement of the 19x25 SS wire.

  • To determine the interfaces at which the bond failures occur after bracket breakage.

    Data on adhesive remnant will be collected from the tooth surface immediately after bracket breakage.

Study Arms (2)

Pumice prophylaxis.

ACTIVE COMPARATOR

Will receive pumice prophylaxis in a slurry of plain pumice and water for 5 seconds per tooth using a rubber cup in a slow contra-angle handpiece. The teeth involved will then be washed and dried prior to using the self etch primer.

Other: Pumice prophylaxis

No pumice prophylaxis.

EXPERIMENTAL

Will not receive pumice prophylaxis. Teeth will be washed and dried before using the self etch primer.

Other: No pumice prophylaxis

Interventions

Pumicing the teeth is the recommended prophylaxis to be used prior to the application of the self etch primer by the manufacturer - 3M Unitek Transbond Plus Self Etch Primer which will be used in the experiment.

Also known as: Pumice slurry, Pumice powder
Pumice prophylaxis.

Pumice prophylaxis will not be used as per manufacturers instructions.

No pumice prophylaxis.

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients receiving fixed appliance therapy with only metal brackets on both upper and lower arches.
  • Good oral hygiene.
  • Balanced extractions in both upper and lower arches.
  • Right-handed patients

You may not qualify if:

  • Enamel defects, hypoplasia or buccal restorations that would preclude bonding to enamel.
  • Orthognathic cases.
  • Surgically exposed teeth or teeth where bracket placement will be delayed.
  • Patients with craniofacial anomalies.
  • Previous use of fixed appliances.
  • Patients that will require partial ligation of teeth immediately after bond-up.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Burgess AM, Sherriff M, Ireland AJ. Self-etching primers: is prophylactic pumicing necessary? A randomized clinical trial. Angle Orthod. 2006 Jan;76(1):114-8. doi: 10.1043/0003-3219(2006)076[0114:SPIPPN]2.0.CO;2.

  • Lill DJ, Lindauer SJ, Tufekci E, Shroff B. Importance of pumice prophylaxis for bonding with self-etch primer. Am J Orthod Dentofacial Orthop. 2008 Mar;133(3):423-6; quiz 476.e2. doi: 10.1016/j.ajodo.2006.03.039.

Study Officials

  • Dr Kaminii Thevadass, BDS

    Department of Paediatric Dentistry and Orthodontics,University of Malaya.

    PRINCIPAL INVESTIGATOR
  • Prof Dr Siti Adibah Othman, BDS

    Department of Paediatric Dentistry and Orthodontics,University of Malaya.

    STUDY DIRECTOR
  • Dr Nor Nadia Zakaria, BDS

    Department of Paediatric Dentistry and Orthodontics,University of Malaya.

    STUDY DIRECTOR

Central Study Contacts

Dr Kaminii Thevadass, BDS

CONTACT

Dr Nor Nadia Zakaria, BDS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Masking Details
The procedures, data collection and data analysis will be done by the orthodontic post-graduate student who is the main investigator in this study, and will not be blinded.The patients will be blinded. This will be done by pumicing the occlusal surfaces of the teeth that are in the study quadrant, and the labial surfaces of the teeth in the control quadrant. The trial is hence a single-blinded study.
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Model Details: Participants will be placed in two different groups based on the randomization and will receive, or not receive the intervention, which is pumicing prior to bond-up, for the duration of the study.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

October 17, 2019

First Posted

October 18, 2019

Study Start

November 1, 2019

Primary Completion

February 1, 2021

Study Completion

March 1, 2021

Last Updated

October 21, 2019

Record last verified: 2019-10

Data Sharing

IPD Sharing
Will not share

Consent has not yet been gained from participants as recruiting has not begun.