Atrificial Shrinkage of Blastocyst Before In Vitro Fertilization

NCT04125017 | Completed DMC

• 1 other identifier: blastocyst preparation
• Study Type: interventional
• Target: 409
• Locations: 1 country
• Sites: 1

Brief Summary

Vitrification is a modern cryopreservation technique based on sudden cooling of reproductive cells to a temperature of -196 ° C in seconds that produces glass-like solidification of a solution without crystallization, but by extreme elevation in viscosity during freezing

Conditions

Infertility

Outcome Measures

Primary Outcomes (1)

• The number of women who will have positive pregnancy test

  The number of women who will come pregnant after each technique

  2 months

Study Arms (2)

effect of using LASER pulse

OTHER

effect of using LASER pulse versus micro-needle use in the artificial shrinkage of blastocysts as a previous step before vitrification in regarding their effect on embryo viability

Device: ICSI with laser pulse; Device: ICSI with micro needle technique

Micro-needle Technique

OTHER

effect of using LASER pulse versus micro-needle use in the artificial shrinkage of blastocysts as a previous step before vitrification in regarding their effect on embryo viability

Device: ICSI with laser pulse; Device: ICSI with micro needle technique

Interventions

ICSI with laser pulse DEVICE

Using laser pulse before ICSI

Micro-needle Technique; effect of using LASER pulse

ICSI with micro needle technique DEVICE

Using micro needle technique before ICSI

Micro-needle Technique; effect of using LASER pulse

Eligibility Criteria

• Age: 20 Years - 44 Years
• Gender Eligibility Details: Females who have infertility
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• women with infertility from 20 to 44 years

You may not qualify if:

• women with age more than 44 or less than 20

Sponsors & Collaborators

• Aljazeera Hospital: lead
• Adam International Hospital: collaborator

Study Sites (1)

Adam

Giza, Egypt

Location

Related Publications (1)

• Kamel Mohamed M, El-Noury MAH, Amer MK, Fakhry E, Alalfy M. Comparative study between two techniques for artificial shrinkage of blastocysts prior to vitrification: LASER pulse versus micro-needle technique in increasing chemical, clinical pregnancy and live birth rates after ICSI, a randomized controlled trial. J Matern Fetal Neonatal Med. 2022 Dec;35(25):4910-4917. doi: 10.1080/14767058.2021.1873265. Epub 2021 Feb 28.

  PMID: 33645399 DERIVED

MeSH Terms

Conditions

Infertility

Interventions

Sperm Injections, Intracytoplasmic

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Fertilization in Vitro; Reproductive Techniques, Assisted; Reproductive Techniques; Therapeutics; Investigative Techniques

Study Officials

• manal kamel

  Adam hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant of Obstetrics and Gynecology

Model Details: effect of using LASER pulse versus micro-needle use in the artificial shrinkage of blastocysts .

Study Record Dates

• First Submitted: October 10, 2019
• First Posted: October 14, 2019
• Study Start: January 1, 2019
• Primary Completion: January 4, 2020
• Study Completion: February 5, 2020
• Last Updated: October 10, 2023

Record last verified: 2023-10

Locations

EG (1)