The Association Between Blood Eosinophilsp in Thai COPD Patients: A Prospective Study
1 other identifier
observational
145
1 country
1
Brief Summary
The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2018
CompletedFirst Submitted
Initial submission to the registry
October 8, 2019
CompletedFirst Posted
Study publicly available on registry
October 10, 2019
CompletedOctober 11, 2019
October 1, 2019
1.1 years
October 8, 2019
October 9, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Acute worsening of respiratory symptoms
acute severe worsening of respiratory symptoms
1 year
Secondary Outcomes (2)
Physiological outcomes
1 year
health related quality of life
1 year
Study Arms (2)
eosinophilic COPD patient
COPD patient with blood eosinophil equal or \> 300 cells/µL
non-eosinophilic COPD patient
COPD patient with blood eosinophil \< 300 cells/µL
Interventions
observation for 1 year period
Eligibility Criteria
Thai COPD patients in out-patient department
You may qualify if:
- diagnosis of COPD by GOLD criteria
You may not qualify if:
- high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection
- Patients who had previous acute exacerbation within 30-day before study entry
- Patients who had previous systemic corticosteroids used within 30-day before study entry
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Faculty of Medicine, Prince of Songkla university
Songkhla, 90110, Thailand
Related Publications (2)
Bafadhel M, Pavord ID, Russell REK. Eosinophils in COPD: just another biomarker? Lancet Respir Med. 2017 Sep;5(9):747-759. doi: 10.1016/S2213-2600(17)30217-5. Epub 2017 Jun 7.
PMID: 28601554BACKGROUNDJuthong S, Kaenmuang P. Association between blood eosinophils with exacerbation and patient-reported outcomes in chronic obstructive pulmonary disease patients in an endemic area for parasitic infections: a prospective study. J Thorac Dis. 2020 Sep;12(9):4868-4876. doi: 10.21037/jtd-19-4101.
PMID: 33145060DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Kanung Saejiam, MS
Prince of Songkla University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Faculty of Medicine
Study Record Dates
First Submitted
October 8, 2019
First Posted
October 10, 2019
Study Start
December 1, 2017
Primary Completion
December 31, 2018
Study Completion
December 31, 2018
Last Updated
October 11, 2019
Record last verified: 2019-10