NCT04117230

Brief Summary

The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing ECMO or Impella implantation at all included sites. All patients undergoing ECMO and/or IMPELLA implantation will be prospectively registered. Device use is according to the decision of the treating physician and independent of this registry.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,500

participants targeted

Target at P75+ for all trials

Timeline
100mo left

Started Aug 2019

Longer than P75 for all trials

Geographic Reach
1 country

5 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress45%
Aug 2019Aug 2034

Study Start

First participant enrolled

August 9, 2019

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

October 3, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 7, 2019

Completed
14.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2034

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2034

Last Updated

December 6, 2024

Status Verified

December 1, 2024

Enrollment Period

15.1 years

First QC Date

October 3, 2019

Last Update Submit

December 3, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Number of deceased participants at 1 month after cardiogenic shock

    All-cause mortality at 30 days

    30 days

Secondary Outcomes (9)

  • Statistical and medical analysis of major adverse cardiac and cerebrovascular events (MACCE) reported by participants

    6 months

  • Statistical and medical analysis of vascular complications (VARC) reported by participants

    6 months

  • Statistical and medical analysis of vascular surgery needed by participants

    6 months

  • Statistical and medical analysis of bleeding complications (minor, major) reported by participants

    6 months

  • Implantation time of MCS-device

    6 months

  • +4 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

In an all-comers design, every patient receiving an MCS will be included.

You may qualify if:

  • Age \> 18 years
  • Medical indication for implantation of a peripheral cannulated VA-ECMO or microaxial flow pump (IMPELLA) or newer LV / LA-Ascending Aorta devices.
  • Signed informed consent by patient or relative or waived consent by EC

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

Universitätsspital Basel

Basel, 4053, Switzerland

RECRUITING

Insel Gruppe AG, Inselspital Bern

Bern, 3010, Switzerland

RECRUITING

Luzerner Kantonsspital

Lucerne, 3600, Switzerland

RECRUITING

Kantonsspital Winterthur

Winterthur, 8400, Switzerland

RECRUITING

Stadtspital Treimli

Zurich, 8063, Switzerland

RECRUITING

MeSH Terms

Conditions

Shock, Cardiogenic

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisShock

Study Officials

  • Lukas C Hunziker Munsch, Prof MD

    University of Bern

    STUDY CHAIR

Central Study Contacts

Lukas C Hunziker Munsch, Prof MD

CONTACT

Monika Fürholz, MD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Months
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 3, 2019

First Posted

October 7, 2019

Study Start

August 9, 2019

Primary Completion (Estimated)

August 31, 2034

Study Completion (Estimated)

August 31, 2034

Last Updated

December 6, 2024

Record last verified: 2024-12

Locations