The Association Between Serum E2 and P on the Day of FET and the Pregnancy Outcome

NCT04114500 | Completed DMC

• 1 other identifier: KAMAL
• Study Type: observational
• Target: 402
• Locations: 1 country
• Sites: 1

Brief Summary

The outcomes of frozen embryo transfer (FET) have substantially improved over the last decade, due to the improvements in the cryopreservation process, Artificial endometrial preparation is typically accomplished by the administration of estradiol (E2) supplementation and exogenous progesterone (P) in order to transform the endometrium into a secretory one, mimicking a natural cycle , The current study aims to determine the association, if any, between serum E2 and P levels, measured same day of FET, and pregnancy outcome

Conditions

Frozen Embryo Transfer

Keywords

Estradiol; FET; IVF; Progesterone

Outcome Measures

Primary Outcomes (2)

• Pregnancy rate

  B-hCG

  2 weeks

• clinical pregnancy rate

  positive fetal heart beat

  4 weeks

Interventions

serum estradiol and progesterone DIAGNOSTIC_TEST

blood sample for measuring serum estradiol and progesterone level on the same day of FET

Eligibility Criteria

• Age: 22 Years - 40 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients undergoing IVF/FET were recruited from April 2018 to September 2019.

You may qualify if:

• patients who underwent frozen-thawed embryos transfer treatment
• the endometrial preparation was initiated with oral estradiol valerate
• the endometrial thickness was no less than 8 mm on the day when P was administrated;
• normal endometrial ultrasound imaging
• euploid pre-genetically tested embryos

You may not qualify if:

• age\> 40 years
• BMI \> 35
• abnormal ultrasonogram of uterine cavity
• abnormal embryos not suitable for transfer

Sponsors & Collaborators

• Al Baraka Fertility Hospital: lead

Study Sites (1)

Al-BARAKA FERTILITY HOSPITAL

Manama, Adliya, 15006, Bahrain

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor , medical director

Study Record Dates

• First Submitted: September 22, 2019
• First Posted: October 3, 2019
• Study Start: April 3, 2018
• Primary Completion: May 1, 2019
• Study Completion: May 5, 2019
• Last Updated: July 8, 2020

Record last verified: 2020-07

Locations

BA (1)