Objective Sepsis Identification Tool to Study Sepsis Epidemiology
Development of an Objective Sepsis Identification Tool to Study Sepsis Epidemiology: a Single Center Retrospective Cohort Study
1 other identifier
observational
490
1 country
1
Brief Summary
Globally, sepsis affects an estimated 31.5 million people and accounts for 5.3 million deaths each year. This calculation is based on data from western high income countries only. The purpose of this study is to develop an objective sepsis identification tool using electronic health records to study the epidemiology of sepsis in Hong Kong.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 10, 2019
CompletedFirst Submitted
Initial submission to the registry
October 1, 2019
CompletedFirst Posted
Study publicly available on registry
October 3, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 10, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
October 15, 2019
CompletedMay 6, 2020
May 1, 2020
1 month
October 1, 2019
May 4, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Classification of Sepsis
comparison with clinician review of case notes
within 2 days of microbiological sampling
Secondary Outcomes (3)
Organ Dysfunction
within 2 days of microbiological sampling
28 Day Mortality
28 days
Hospital Length of Stay
1 year
Study Arms (1)
patients with suspected infection or sepsis
All patients admitted with suspected infection or sepsis from January 2018 to February 2018 at Prince of Wales Hospital
Eligibility Criteria
All adult patients admitted to Prince of Wales Hospital in Hong Kong between January 2018 to February 2018 with suspected infection.
You may qualify if:
- January 2018 to February 2018 adult inpatients at Prince of Wales Hospital
- st microbiological culture tests during hospital admission
You may not qualify if:
- duplicated microbiological sampling
- missing values for sequential organ failure assessment score calculation
- microbiological tests were for screening only (methicillin-resistant staphylococcus aureus swabs, vancomycin resistant Enterococci rectal swab)
- antibiotics not started 2 days before or after first microbiological sampling
- antibiotics duration less than 4 days unless death
- not given antibiotics on discharge if given less than 4 days antibiotics in hospital
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Prince of Wales Hospital
Hong Kong, Hong Kong
Related Publications (1)
Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L. A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC Infect Dis. 2020 Sep 7;20(1):652. doi: 10.1186/s12879-020-05330-x.
PMID: 32894059DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Lecturer
Study Record Dates
First Submitted
October 1, 2019
First Posted
October 3, 2019
Study Start
September 10, 2019
Primary Completion
October 10, 2019
Study Completion
October 15, 2019
Last Updated
May 6, 2020
Record last verified: 2020-05
Data Sharing
- IPD Sharing
- Will not share