Effects of Post-exercise Protein Supplementation in Young Athletes

NCT04114045 | Completed

• 1 other identifier: 16-279 Klentrou
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This randomised double blind, placebo-controlled study examined the effects of post-exercise consumption of whey protein (PRO) or carbohydrate (CHO) on performance recovery, muscle damage and inflammatory cytokine responses following a high intensity interval swim (HIIS) in 10-17-year old male and female swimmers.

Conditions

Fatigue; Inflammation; Bone Resorption

Outcome Measures

Primary Outcomes (7)

• Performance recovery

  200m front crawl time (s) measured in short course pool (25m)

  24 hours

• IL-6 (pg/ml)

  Myokine

  24 hours

• IL-10 (pg/ml)

  Anti-inflammatory cytokine

  24 hours

• TNF-alpha (pg/ml)

  Pro-inflammatory cytokines

  24 hours

• Muscle damage

  Creatine kinase activity (u/L)

  24 hours

• Bone formation marker

  Procollagen type 1 intact N-terminal propeptide, PINP (ng/ml)

  24 hours

• Bone resorption marker

  Carboxy-terminal collagen crosslinks, CTXI (ng/ml)

  24 hours

Secondary Outcomes (2)

• Bone turnover balance

  24 hours

• Rate of Bone turnover

  24 hours

Study Arms (3)

Whey protein

EXPERIMENTAL

Whey protein isolate

Dietary Supplement: Experimental:Whey protein

Isoenergetic control - Carbohydrate

ACTIVE COMPARATOR

Carbohydrate or maltodextrin

Dietary Supplement: Active Comparator: Isoenergetic control - Carbohydrate

Placebo control - Water

PLACEBO COMPARATOR

Water - chocolate flavoured

Other: Placebo

Interventions

Experimental:Whey protein DIETARY_SUPPLEMENT

Each participant in the protein group received 2 protein drinks immediately following exercise. The supplement was given using a relative quantity of whey protein isolate (0.3g/kg) and was chocolate flavoured.

Whey protein

Active Comparator: Isoenergetic control - Carbohydrate DIETARY_SUPPLEMENT

Each participant in the carbohydrate group received 2 drinks immediately following exercise. The supplement was given using a relative quantity of maltodextrin (0.3g/kg), non-caloric chocolate flavouring was added to mask the drinks contents.

Isoenergetic control - Carbohydrate

Placebo OTHER

Each participant in the water group received 2 drinks immediately following exercise. The water was provided in a similar volume using the same non-caloric chocolate flavouring as the other drinks.

Placebo control - Water

Eligibility Criteria

• Age: 11 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• competitive swimmers (swim competitively for a minimum of 2y)
• male or female 11-17y
• free from any medical conditions

You may not qualify if:

• yes on medical screening questionnaire
• not classified as a competitive swimmer (swim competitively for \<2y)
• outside the desired age range (\<11 or \>17)

Sponsors & Collaborators

• Brock University: lead

Study Sites (1)

Brock University

Saint Catharines, Ontario, L2S 3A1, Canada

Location

Related Publications (3)

• McKinlay BJ, Theocharidis A, Adebero T, Kurgan N, Fajardo VA, Roy BD, Josse AR, M Logan-Sprenger H, Falk B, Klentrou P. Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers. Int J Environ Res Public Health. 2020 Oct 23;17(21):7761. doi: 10.3390/ijerph17217761.

  PMID: 33114186 RESULT

• Theocharidis A, McKinlay BJ, Vlachopoulos D, Josse AR, Falk B, Klentrou P. Effects of post exercise protein supplementation on markers of bone turnover in adolescent swimmers. J Int Soc Sports Nutr. 2020 Apr 15;17(1):20. doi: 10.1186/s12970-020-00350-z.

  PMID: 32293471 RESULT

• Sanderson M, McKinlay BJ, Theocharidis A, Kouvelioti R, Falk B, Klentrou P. Changes in Inflammatory Cytokines and Irisin in Response to High Intensity Swimming in Adolescent versus Adult Male Swimmers. Sports (Basel). 2020 Dec 1;8(12):157. doi: 10.3390/sports8120157.

  PMID: 33271764 RESULT

MeSH Terms

Conditions

Fatigue; Inflammation; Bone Resorption

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Bone Diseases; Musculoskeletal Diseases

Study Officials

• Panagiota Klentrou, PhD

  Brock University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: One member of the research team whom did not have direct contact with participant during performance testing, matched participants for age, sex and body mass into one of three groups (protein, carbohydrate or placebo/water). This member of the research team also prepared and distributed all the research supplements in a sealed black opaque containers
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Associate Dean

Model Details: Participants were divided into three groups: PRO (0.3g/kg - whey protein isolate), CHO (0.3g/kg - maltodextrin) or placebo control (H2O), matched for age, sex and body mass

Study Record Dates

• First Submitted: September 30, 2019
• First Posted: October 3, 2019
• Study Start: December 19, 2016
• Primary Completion: May 24, 2018
• Study Completion: September 18, 2018
• Last Updated: June 2, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)