Correlation Between Quality of Life and Severity of Parkinson's Disease

NCT04110106 | Completed

• 1 other identifier: Quality of Life and Parkinson
• Study Type: observational
• Target: 513
• Locations: 1 country
• Sites: 1

Brief Summary

This study aim to evaluate the correlation between Quality of Life (QoL) and severity of Parkinson's Disease (PD) by assessing the presence of an optimal cut-off point on the Parkinson's disease questionnaire (PDQ-39) as related to the Hoehn \& Yahr (H\&Y) scale in a cohort of Italian adults with PD. A multicenter, cross-sectional study was performed in central and northern Italy. This study was conducted on a cohort of consecutive individuals at three neurologic outpatient clinics. All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H\&Y scale by a neurologist. Receiver operating characteristic (ROC) curves and coordinates of the curve, which were visually inspected, were used to find cut-off points with optimal sensitivity and specificity. These were in turn used to determine the optimal PDQ-39 cut-off score for identifying disease severity according to H\&Y stages.

Conditions

Parkinson Disease; Quality of Life

Outcome Measures

Primary Outcomes (2)

• Hoehn & Yahr (H&Y)

  severity of Parkinson's disease

  at admission to the neurologic outpatient clinics

• Parkinson's Disease questionnaire (PDQ-39)

  quality of life

  at admission to the neurologic outpatient clinics

Interventions

no intervention OTHER

All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H\&Y scale by a neurologist.

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Fivehundred thirteen individuals with Parkinson's Disease (PD) were recruited, all of whom agreed to participate and were thus included in the study. From the general analysis resulted that the greatest number of participants were stage II, according to Hoehn \& Yahr (H\&Y), followed by stage III, stage I, and finally stage IV. Participants between the age of 50 and 69 were mainly stage I or II, while participants aged 70 to 89 had a greater severity of PD (stage II and III). Most women were in H\&Y stage II and III, while most men were mainly in stage II, followed by stage I and III, with a very similar number of participants. A common result for all analyses was the presence of a very low number of participants with stage IV.

You may qualify if:

• age \> 50 but \< 90 years,
• H\&Y stages I, II, III, and IV,
• a mini-mental state examination \> 22 points,
• a minimum level of five years of education.

You may not qualify if:

• Individuals with emotional or psychiatric problems (as determined by clinical screening)

Sponsors & Collaborators

• R.O.M.A. - Rehabilitation & Outcome Measures Assessment: lead

Study Sites (1)

Department of Human Neurosciences, Sapienza University of Rome

Roma, RM, 00185, Italy

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Public Health and Infection disease, Sapienza University of Rome

Study Record Dates

• First Submitted: September 28, 2019
• First Posted: October 1, 2019
• Study Start: February 1, 2018
• Primary Completion: March 25, 2019
• Study Completion: September 25, 2019
• Last Updated: October 1, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will share

Locations

IT (1)