Evaluation of Diagnostic Performance of Cerebral Perfusion Scans in Pseudo-Stroke

NCT04105257 | Completed

• 1 other identifier: CE19.072
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

When a patient is received with the context of acute stroke, they undergo a fast neurological evaluation and obtain a basic appraisal composed of a non-contrast endovascular cerebral scan and an angiography scan of intracranial blood vessels and the neck. Once the structural lesion (hemorrhage, tumor, etc.) is absent, signs of early infracts and confirmed acute intracranial arterial occlusion, the possibility of a pseudo-stroke dwells in the differential diagnostic. Certain characteristics of history and clinical evaluation create sufficient doubt to evoke the possibility of a pseudo-stroke. In fact, this population is mostly female and the cardiovascular risk factors are less prevalent in this group than for the group of stroke victims. It is on average the youngest and presents a less severe deficit. For the rest, medical antecedents often help to evoke a diagnosis of pseudo-stroke.

Conditions

Stroke, Acute

Outcome Measures

Primary Outcomes (2)

• Sensibility

  proportion of patients that are correctly identified as having a pseudo-stroke

  : Immediately after the procedure (CTP scan/MRI)

• Specificity

  proportion of patient that are correctly identified as not having a pseudo-stroke

  Immediately after the procedure (CTP scan/MRI)

Study Arms (1)

All patients

OTHER

All patients seen at emergency with acute neurological deficit will be assessed if eligible to CTP/MRI

Diagnostic Test: All patients

Interventions

All patients DIAGNOSTIC_TEST

Comparison of the results of the CTP with MRI

All patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Admission at CHUM for acute neurological deficit \<4,5h (since the onset of symptoms)
• Potential candidate for an intravenous thrombolysis
• Cerebral angioscan performed at CHUM at the time of admission
• Age ≥ 18 years
• Observed period from September 2019 à June 2020

You may not qualify if:

• Contraindication to intravenous thrombolysis according to the doctor in charge of treatment;
• Indication of a thrombectomy;
• Incomplete exam or exam of insufficient technical quality for a reliable radiological interpretation;
• Contraindication against MRI .

Sponsors & Collaborators

• Centre hospitalier de l'Université de Montréal (CHUM): lead

Study Sites (1)

Centre hospitalier de l'Université de Montréal (CHUM)

Montreal, QC - Québec, H2X0C1, Canada

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Francois Guilbert, MD

  Centre hospitalier de l'Université de Montréal (CHUM)

  PRINCIPAL INVESTIGATOR

• Laura Gioia, MD

  Centre hospitalier de l'Université de Montréal (CHUM)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 23, 2019
• First Posted: September 26, 2019
• Study Start: October 20, 2019
• Primary Completion: October 4, 2022
• Study Completion: October 4, 2022
• Last Updated: December 12, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)