NCT04104308

Brief Summary

To assess the associations between egg and dietary cholesterol consumption with mortality and metabolic syndrome (MetS).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33,453

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 1991

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1991

Completed
24 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2015

Completed
12 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2015

Completed
3.7 years until next milestone

First Submitted

Initial submission to the registry

September 24, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 26, 2019

Completed
Last Updated

March 15, 2024

Status Verified

March 1, 2024

Enrollment Period

24 years

First QC Date

September 24, 2019

Last Update Submit

March 12, 2024

Conditions

MetsDeath

Outcome Measures

Primary Outcomes (1)

  • mortality

    mortality

    participants were followed up from 1991 to 2015

Secondary Outcomes (1)

  • metabolic syndrome

    The blood samples were collected in 2009 for the first time.

Eligibility Criteria

Sexall
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The CHNS is a nationwide cohort survey in China, which was established as a joint project of the University of North Carolina at Chapel and the China Center for Disease Control and Prevention (CCDC).This national-wide survey adopted a novel measure from multiple dimensions, which helped to understand how the long-term social and economic changes affected nutrition and health-related outcomes of Chinese. Until now, 10 rounds of survey (1989, 1991, 1993, 1997, 2000, 2004, 2006, 2009, 2011 and 2015) have been conducted.

You may qualify if:

  • participants aged ≥20 y

You may not qualify if:

  • missing creatinine, age, cannot be linked to socio-demographic data; aged less than 20; without complete dietary data .

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Wu F, Zhuang P, Zhan C, Shen X, Jiao J, Zhang Y. Egg and Dietary Cholesterol Consumption and the Prevalence of Metabolic Syndrome: Findings from a Population-Based Nationwide Cohort. J Acad Nutr Diet. 2022 Apr;122(4):758-770.e5. doi: 10.1016/j.jand.2021.09.010. Epub 2021 Oct 11.

    PMID: 34506988DERIVED

  • Zhuang P, Jiao J, Wu F, Mao L, Zhang Y. Egg and egg-sourced cholesterol consumption in relation to mortality: Findings from population-based nationwide cohort. Clin Nutr. 2020 Nov;39(11):3520-3527. doi: 10.1016/j.clnu.2020.03.019. Epub 2020 Mar 28.

    PMID: 32307193DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

The blood samples were collected in 2009 for the first time

MeSH Terms

Conditions

Death

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

September 24, 2019

First Posted

September 26, 2019

Study Start

January 1, 1991

Primary Completion

January 1, 2015

Study Completion

December 31, 2015

Last Updated

March 15, 2024

Record last verified: 2024-03