Neural Correlates of Knee Sensorimotor Control in Patients With Patellofemoral Pain Syndrome

NCT04099004 | Completed

• 2 other identifiers: STUDY000017732017-5776
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to determine the neural correlates of knee motor control in young females with patellofemoral pain (PFP). Each participant will attend a single study visit which may last up to 3 hours.

Conditions

Patellofemoral Pain Syndrome; Patellofemoral Pain

Outcome Measures

Primary Outcomes (4)

• Resting State Blood Oxygen Level Dependent (BOLD) Signal

  Brain activity while the participant is lying still will be assessed as the BOLD signal obtained using fMRI.

  Day 1 (during MRI session)

• Blood Oxygen Level Dependent (BOLD) Signal During Flexion/Extension Movement

  Brain activity while participants complete a combined knee and hip flexion/extension movement will be assessed as the BOLD signal obtained using fMRI.

  Day 1 (during MRI session)

• Blood Oxygen Level Dependent (BOLD) Signal During Quadriceps Contraction

  Brain activity while participants complete a a quadriceps contraction task will be assessed as the BOLD signal obtained using fMRI. For the quadriceps contraction task, participants are asked to 'squeeze' their quadriceps while keeping the rest of their body still.

  Day 1 (during MRI session)

• Blood Oxygen Level Dependent (BOLD) Signal During Pain Inducing Tasks

  Brain activity while participants complete pain inducing tasks will be assessed as the BOLD signal obtained using fMRI. The pain inducing tasks involve the researcher placing one hand above the participants' knee and applying intermittent pressure to their quadriceps and medial aspect of the patella.

  Day 1 (during MRI session)

Secondary Outcomes (4)

• Pain Scale Score

  Day 1 (during MRI session)

• Anterior Knee Pain Scale (AKPS) Score

  Day 1 (during MRI session)

• International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form Score

  Day 1 (during MRI session)

• Tampa Scale of Kinesiophobia (TSK) Score

  Day 1 (during MRI session)

Study Arms (1)

Neural Imaging

OTHER

Females with PFP attending a single study visit where neural imaging is acquired via MRI.

Other: Neural Imaging

Interventions

Neural Imaging OTHER

During the acquisition of magnetic resonance (MR) images, the study participants will lie on the scanner table. For most portions of MR acquisition, the study participants will be instructed to lie still. For other parts of the acquisition, study participants will be asked to complete a combined knee and hip flexion/extension movement and a quadriceps contraction task in which they will be asked to 'squeeze' their quadriceps while keeping the rest of their body still. For the last 15 minutes of MR acquisition, the researcher will place one hand above the participants' knee and apply intermittent pressure to their quadriceps and medial aspect of the patella. Pain scales will be administered after every fMRI task to assess subjective perceptions of pain. Peripheral pulse oximetry and respiration waveforms will be collected for data analysis in order to minimize the potential confounding effect from the physiological changes.

Neural Imaging

Eligibility Criteria

• Age: 7 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Diagnosed with patellofemoral pain (PFP) or anterior knee pain by a medical professional
• Able to provide written consent

You may not qualify if:

• Any contraindications to MRI

Sponsors & Collaborators

• Emory University: lead

Study Sites (2)

Emory Healthcare Sports Performance And Research Center (SPARC)

Flowery Branch, Georgia, 30542, United States

Location

Cincinanti Childrens Hospital Medical Center (CCHMC)

Cincinnati, Ohio, 45229, United States

Location

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Officials

• Gregory D Myer, PhD

  Emory University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 11, 2019
• First Posted: September 23, 2019
• Study Start: November 16, 2017
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: February 13, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)