Epidemiology of Carbapenemase-producing Bacteria in a Swiss Tertiary Care Hospital

NCT04098133 | Recruiting

• 1 other identifier: 2019-01548; me19Tschudinsutter
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective and prospective study is to investigate the incidence of Carbapenemase-producing bacteria (CPB) at the University Hospital Basel, the time to detection of CPB and to initiation of infection control measures, the risk factors associated with carriage of CPB, type and duration of previously administrated antibiotic medication, antibiotic treatment, as well as to assess the outcomes of the affected patients.

Conditions

Infections With CPB

Keywords

Carbapenemase-producing Klebsiella pneumoniae; antibiotic resistancy; infections with Carbapenemase-producing Bacteria (CPB); Carbapenemase-producing Bacteria

Outcome Measures

Primary Outcomes (1)

• incidence of CPB at the University Hospital Basel (number)

  incidence of CPB at the University Hospital Basel (number)

  from January 1st , 2008 until December 31st, 2028

Secondary Outcomes (9)

• time to detection of CPB (days)

  from January 1st , 2008 until December 31st, 2028

• time to initiation of infection control measures

  from January 1st , 2008 until December 31st, 2028

• time to adequate treatment in patients with CPB infections

  from January 1st , 2008 until December 31st, 2028

• presence of established risk factors for CPB

  from January 1st , 2008 until December 31st, 2028

• length of hospital stay (days)

  from January 1st , 2008 until December 31st, 2028

Interventions

data collection for demographic data OTHER

data collection for demographic data (age, gender, hospital admission and discharge date, length of stay, hospitalization prior to current hospital stay (acute care facilities, long-term healthcare centres, nursing homes), discharge destination, outcome, cause of death, travel history, previous exposure to antibiotics and proton pump Inhibitors)

data collection for clinical data OTHER

data collection for clinical data (comorbidities, Charlson Comorbidity Index, immunosuppressive treatment, date of diagnosis of CPB, days between hospital admission and diagnosis of CPB, type of consecutive infection, indwelling vascular hardware, urinary catheterization, surgical therapies)

data collection for treatment data OTHER

data collection for treatment data (antibiotic therapy, immunosuppressive therapy, concomitant medication)

data collection for microbiological data OTHER

data collection for microbiological data (species of CPB, type of sample, date of sample, history of colonization or infection with any antibiotic resistant pathogen)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients treated in the in- or outpatient setting at the University Hospital Basel with detection of carbapenemase-producing bacteria in any screening or clinical sample from January 1st , 2008 until December 31st , 2028

You may qualify if:

• Patients with detection of carbapenemase-producing bacteria from January 1st , 2008 until December 31st , 2028

You may not qualify if:

• Patients with documented refusal of subsequent use of their data

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

Division of Infectious Diseases and Hospital Epidemiology

Basel, 4031, Switzerland

RECRUITING

MeSH Terms

Interventions

Data Collection; Demography

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Population Characteristics; Epidemiologic Measurements

Study Officials

• Sarah Tschudin Sutter, Prof. Dr. MD

  University Hospital Basel, Division of Infectious Diseases and Hospital Epidemiology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sarah Tschudin Sutter, Prof. Dr. MD

CONTACT

+41 61 328 68 10; sarah.tschudin@usb.ch

Isabelle Vock, Dipl. med

CONTACT

isabelle.vock@usb.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 17, 2019
• First Posted: September 23, 2019
• Study Start: August 22, 2019
• Primary Completion (Estimated): June 30, 2029
• Study Completion (Estimated): June 30, 2029
• Last Updated: June 8, 2026

Record last verified: 2026-06

Locations

CH (1)