Impact of Maternal BMI on Plasma Levels of Oxytocin During Labor Augmentation

NCT04093479 | Completed

• 1 other identifier: 110930ingo
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to examine the associations between maternal BMI and levels of oxytocin in maternal plasma during augmentation with oxytocin during first stage of labor in term pregnancy.

Conditions

Maternal Obesity During Childbirth; Labor; Arrested Active Phase

Keywords

labor; obesity; oxytocin

Outcome Measures

Primary Outcomes (2)

• maternal BMI, were weight and height will be combined to report BMI in kg/m^2

  mass spectrometry

  eight hours

• level of oxytocin in plasma during oxytocin infusion

  mass spectrometry

  eight hours

Study Arms (1)

BMI, oxytocin

Repeteadly blood samples will be taken

Other: blood samples

Interventions

blood samples OTHER

blood samples will be taken repeatedly

BMI, oxytocin

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Full-term pregnancy (from gestational week 37+0), singel pregnancy, vertex presentation, knowledge in the Swedish language, 18 years and older, known BMI, need of labor augmentation with oxytocin infusion during opening stage.

You may qualify if:

• Full-term pregnancy (from gestational week 37+0), singel pregnancy, vertex presentation, knowledge in the Swedish language, 18 years and older, known BMI, need of labor augmentation with oxytocin infusion during opening stage.

You may not qualify if:

• Not participating in other studies at the delivery ward

Sponsors & Collaborators

• Linkoeping University: lead

Study Sites (1)

Department of Obstetrics

Linköping, 58185, Sweden

Location

Related Publications (1)

• Ramo Isgren A, Carlhall S, Dennis Retrato M, Kodikara C, A Ubhayasekera K, Kjolhede P, Bergquist J, Blomberg M. The association between maternal body mass index and serial plasma oxytocin levels during labor. PLoS One. 2023 Aug 11;18(8):e0290038. doi: 10.1371/journal.pone.0290038. eCollection 2023.

  PMID: 37566578 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

bloodplasma

MeSH Terms

Conditions

Obesity

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Marie Blomberg, PhD

  Linkoeping University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 14, 2019
• First Posted: September 18, 2019
• Study Start: October 1, 2019
• Primary Completion: December 1, 2019
• Study Completion: August 1, 2020
• Last Updated: February 21, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)