NCT04086810

Brief Summary

The primary objective of this study is to monitor the long-term safety of DCCR in PWS patients.

Trial Health

15
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Oct 2019

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 10, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 12, 2019

Completed
19 days until next milestone

Study Start

First participant enrolled

October 1, 2019

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2019

Completed
Last Updated

August 3, 2021

Status Verified

September 1, 2019

Enrollment Period

Same day

First QC Date

September 10, 2019

Last Update Submit

July 29, 2021

Conditions

Keywords

PWSPrader-Willi Syndrome

Outcome Measures

Primary Outcomes (1)

  • Adverse Events (Safety)

    Assess the safety of DCCR by evaluating the incidence and severity of adverse events reported.

    Baseline to Week 106

Study Arms (1)

DCCR

EXPERIMENTAL

25 - 450 mg DCCR

Drug: DCCR

Interventions

DCCRDRUG

Once daily oral administration

DCCR

Eligibility Criteria

Age4 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Successful completion of clinical study C602, Visit 15
  • Provide voluntary, written informed consent (parent(s) / legal guardian(s) of subject); provide voluntary, written assent (subject, as appropriate)
  • Primary caregiver must be able to communicate with Investigator and study site personnel as well as read and complete the study-required questionnaires.

You may not qualify if:

  • Positive urine pregnancy test (in females of childbearing potential)
  • Females who are pregnant or breastfeeding, and/or plan to become pregnant or to breast-feed during or within 90 days after study participation
  • Any new disease, condition, or circumstance, which may significantly impact subject safety

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Prader-Willi Syndrome

Condition Hierarchy (Ancestors)

Intellectual DisabilityNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesAbnormalities, MultipleCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesChromosome DisordersGenetic Diseases, InbornImprinting DisordersObesityOverweightOvernutritionNutrition DisordersNutritional and Metabolic Diseases
0

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 10, 2019

First Posted

September 12, 2019

Study Start

October 1, 2019

Primary Completion

October 1, 2019

Study Completion

October 1, 2019

Last Updated

August 3, 2021

Record last verified: 2019-09