Mycoprotein and Muscle Protein Synthetic Response
PIMP
Comparing the Muscle Protein Synthetic Response to Ingestion of Mycoprotein vs Protein Isolated From Mycoprotein
1 other identifier
interventional
24
1 country
1
Brief Summary
Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients). Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 15, 2019
CompletedFirst Submitted
Initial submission to the registry
September 6, 2019
CompletedFirst Posted
Study publicly available on registry
September 10, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 11, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 11, 2019
CompletedMay 27, 2022
May 1, 2022
8 months
September 6, 2019
May 26, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Muscle protein synthesis
The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)
7.5 hours
Secondary Outcomes (3)
Plasma Amino Acid Kinetics
7.5 hours
Blood Glucose
7.5 hours
Serum Insulin
7.5 hours
Study Arms (2)
Mycoprotein
EXPERIMENTALMycoprotein in its full food matrix
Protein Isolated from Mycoprotein
EXPERIMENTALProtein from mycoprotein isolated from the food matrix
Interventions
The ingestion of mycoprotein
Eligibility Criteria
You may qualify if:
- BMI between 18 and 30.
- Resistance trained
You may not qualify if:
- Any metabolic impairments.
- Cardio/pulmonary diseases.
- Chronic use of over the counter pharmaceuticals
- A personal or family history of epilepsy, seizures or schizophrenia.
- Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Exeterlead
- Quorncollaborator
Study Sites (1)
University of Exeter
Exeter, United Kingdom
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 6, 2019
First Posted
September 10, 2019
Study Start
April 15, 2019
Primary Completion
December 11, 2019
Study Completion
December 11, 2019
Last Updated
May 27, 2022
Record last verified: 2022-05
Data Sharing
- IPD Sharing
- Will not share