Risk Communication in African American Smokers

NCT04084561 | Completed Results

• 2 other identifiers: 18-80041U54CA221705-01A1
• Study Type: interventional
• Target: 166
• Locations: 1 country
• Sites: 2

Brief Summary

The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry. Participants will be given hypothetical personalized genetic risk results and ask to think about how they might respond to such information if they actually received such results.

Conditions

Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Motivation to Quit Smoking

  use self report 7 item (condition options) MTSS (Motivation to Stop Smoking) Scale with yes/no option to determine the quitting intention condition; range of scale : 1-7, with higher score means higher motivation to quit smoking

  1 minute after intervention

Study Arms (4)

HRHA

EXPERIMENTAL

High Risk, High Ancestry

Behavioral: HRHA

LRLA

EXPERIMENTAL

Low Risk, Low Ancestry

Behavioral: LRLA

HRLA

EXPERIMENTAL

High Risk, Low Ancestry

Behavioral: HRLA

LRHA

EXPERIMENTAL

Low Risk, High Ancestry

Behavioral: LRHA

Interventions

HRHA BEHAVIORAL

participants will be asked to consider a hypothetical scenario in which genetic test results reveal that: 1) they carry genotypes that place African American smokers at a particularly high (\~50%-80%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly high concordance with African heritage (\~90%).

HRHA

LRLA BEHAVIORAL

participants will be asked to consider a scenario in which genetic test results reveal that: 1) they are at normal (\~7%-10%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly low concordance with African heritage (\~10%).

LRLA

HRLA BEHAVIORAL

participants will receive "High Risk, Low Ancestry (HRLA)" hypothetical

HRLA

LRHA BEHAVIORAL

participants will receive "Low Risk, High Ancestry (HRLA)" hypothetical

LRHA

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age minimum
• Self-report African American
• Report smoking at least 100 lifetime cigarettes

You may not qualify if:

• Report history of cancer

Sponsors & Collaborators

• Temple University: lead
• National Cancer Institute (NCI): collaborator

Study Sites (2)

Hunter College

New York, New York, 10065, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Limitations and Caveats

This study examined the effects of communicating hypothetical genetic results to patients on their motivation to quit smoking. Future research needs to study effects of actual genetic risk communication, and its effects on actual smoking cessation behavior, rather than motivation to quit. Nevertheless the results suggest communicating elevated risk of lung cancer may increase motivation to quit smoking.

Results Point of Contact

• Title: Dr. Grace X. Ma
• Organization: Center for Asian Health, Temple University

grace.ma@temple.edu

215-707-6493

Study Officials

• Camille Ragin, PhD

  Fox Chase Cancer Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 6, 2019
• First Posted: September 10, 2019
• Study Start: September 1, 2018
• Primary Completion: April 1, 2022
• Study Completion: April 1, 2022
• Last Updated: December 18, 2023
• Results First Posted: December 18, 2023

Record last verified: 2023-11

Locations

US (2)