IS Three d Power Doppler of the Endometrial and Subendometrial Regions Effective in Predicting Endometrial Implantation?

NCT04081870 | Completed DMC

• 1 other identifier: khalid 6
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

Three D power Doppler US was done for every woman at the day after HCG administration. Ovum pick up was done after 35 hours following HCG administration. The luteal phase was supported by progesterone 300 mg per day (progest, micronized progesterone 100mg, Technopharma, Egypt, for pharco pharmaceuticals, Amriya- Alexandria). Five days following ovum pick up, the embryos were transferred at the blastocyst stage.

Conditions

Infertility

Keywords

doppler,endometrial,implantation

Outcome Measures

Primary Outcomes (3)

• chemical pregnancy

  positive pregnancy test

  14 day

• the clinical pregnancy

  was confirmed by TVS for detection of gestational sacs and embryo cardiac activity.

  28 day

• The ongoing pregnancy

  was detected by abdominal ultrasound at 12 weeks.

  3 months

Study Arms (1)

ICSI cases

All women underwent long agonist protocol for controlled ovarian hyperstimulation The GnRH agonist was started in the previous mid-luteal phase . After the confirmation of pituitary down regulation , the HMG ampoules were started by 225 IU/day . During the follow up of overstimulation, the doses were adjusted according to the response of patient. All women underwent serial TVS until at least three dominant follicles were reached in every woman. When the dominant follicles reached 18-20 mm, HCG 10000 was administered. Three D power Doppler US was done for every woman at the day after HCG administration. Ovum pick up was done after 35 hours following HCG administration. The luteal phase was supported by progesterone 300 mg per day . Five days following ovum pick up, the embryos were transferred at the blastocyst stage.

Diagnostic Test: 3D power doppler US

Interventions

3D power doppler US DIAGNOSTIC_TEST

Three D power Doppler US was done for every woman at the day after HCG administration. Ovum pick up was done after 35 hours following HCG administration.

ICSI cases

Eligibility Criteria

• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

infertile women in need for ICSI due to male factor

You may qualify if:

• age; 22-35 years,
• BMI; less than 35 kg/m2,
• Husband with oligo- or oligoasthenospermia.

You may not qualify if:

• \\1-gross uterine and tubal pathology,
• Development of OHSS,
• poor responders,
• failure of oocyte fertilization or failure of the embryos to reach the blastocyst stage and
• Refusal to participate in the study at any step of the ICSI cycle.

Sponsors & Collaborators

• Benha University: lead

Related Publications (1)

• Ledee-Bataille N, Lapree-Delage G, Taupin JL, Dubanchet S, Frydman R, Chaouat G. Concentration of leukaemia inhibitory factor (LIF) in uterine flushing fluid is highly predictive of embryo implantation. Hum Reprod. 2002 Jan;17(1):213-8. doi: 10.1093/humrep/17.1.213.

  PMID: 11756390 RESULT

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Study Officials

• khalid salama

  Benha University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: September 5, 2019
• First Posted: September 9, 2019
• Study Start: February 1, 2014
• Primary Completion: April 1, 2019
• Study Completion: May 1, 2019
• Last Updated: September 11, 2019

Record last verified: 2019-09