Evaluation of Microbial Composition in Human Milk From Healthy Women in the Turkish Population: an Observational Cross-sectional Study
Sponsor study identifier
observational
20
1 country
1
Study Start
May 5, 2018
Actual (reported)Primary Completion
September 5, 2018
Actual (reported)Study Completion
July 5, 2019
Actual (reported)Breast milk is an optimal source of nutrients for newborns as well as a potential source of bacteria for the intestinal microbiota. However, there are limited number of studies evaluating the relationship between maternal nutrition, breast milk and neonatal intestinal microbiota.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 5, 2019
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 5, 2018
Actual (reported)September 5, 2018
Actual (reported)July 5, 2019
Actual (reported)August 27, 2019
Actual (reported)August 28, 2019
Actual (reported)Microbial abundance and diversity
The microbial composition of the breast milk samples was determined by 16S rRNA (ribosomal ribonucleic acid) gene sequencing analysis.
at 16 day postpartum
20 healthy women who were at 16. day postpartum
Hacettepe University
Ankara, Turkey (Türkiye)
Murphy K, Curley D, O'Callaghan TF, O'Shea CA, Dempsey EM, O'Toole PW, Ross RP, Ryan CA, Stanton C. The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study. Sci Rep. 2017 Jan 17;7:40597. doi: 10.1038/srep40597.
Fitzstevens JL, Smith KC, Hagadorn JI, Caimano MJ, Matson AP, Brownell EA. Systematic Review of the Human Milk Microbiota. Nutr Clin Pract. 2017 Jun;32(3):354-364. doi: 10.1177/0884533616670150. Epub 2016 Sep 27.
Breast Milk
Gülhan SAMUR, Professor
Hacettepe University
20 participants (actual enrollment reported by the registry).
First Submitted
August 27, 2019
First Posted
August 28, 2019
Study Start
May 5, 2018
Actual (reported)Contact the study team to confirm eligibility.
Jost T, Lacroix C, Braegger C, Chassard C. Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches. Br J Nutr. 2013 Oct;110(7):1253-62. doi: 10.1017/S0007114513000597. Epub 2013 Mar 14.
Hunt KM, Foster JA, Forney LJ, Schutte UM, Beck DL, Abdo Z, Fox LK, Williams JE, McGuire MK, McGuire MA. Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS One. 2011;6(6):e21313. doi: 10.1371/journal.pone.0021313. Epub 2011 Jun 17.
Chen PW, Lin YL, Huang MS. Profiles of commensal and opportunistic bacteria in human milk from healthy donors in Taiwan. J Food Drug Anal. 2018 Oct;26(4):1235-1244. doi: 10.1016/j.jfda.2018.03.004. Epub 2018 Apr 5.
Damaceno QS, Souza JP, Nicoli JR, Paula RL, Assis GB, Figueiredo HC, Azevedo V, Martins FS. Evaluation of Potential Probiotics Isolated from Human Milk and Colostrum. Probiotics Antimicrob Proteins. 2017 Dec;9(4):371-379. doi: 10.1007/s12602-017-9270-1.
Primary Completion
September 5, 2018
Actual (reported)Study Completion
July 5, 2019
Actual (reported)Last Updated
August 28, 2019
Record last verified: 2019-08
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