Adaptive CT Acquisition for Personalised Thoracic Imaging

NCT04070586 | Completed

• 1 other identifier: HREC/18/LPOOL/361
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient's breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the dynamic patient, personalised images of a patients lungs are able to be acquired for radiotherapy treatments.

Conditions

Cancer, Lung

Keywords

Lung cancer; Radiotherapy; 4DCBCT

Outcome Measures

Primary Outcomes (1)

• RMG-4DCBCT image guidance is feasible for lung cancer patients undergoing radiotherapy

  This will be achieved by performing (offline) analysis of the RMG-4DCBCT images obtained and scoring them on a scale of one (excellent quality for image guidance) to three (unsuitable for image guidance).

  2 years

Secondary Outcomes (1)

• To measure the extent of association between image quality and the patients' breathing conditions.

  2 years

Study Arms (1)

4DCBCT images

4DCBCT images are acquired and assessed offline.

Device: 4DCBCT images

Interventions

4DCBCT images DEVICE

Images are acquired and assessed offline

4DCBCT images

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with lung cancer who will be treated with radiotherapy.

You may qualify if:

• Have the ability to give informed consent
• A diagnosis of lung cancer with an indication for radiotherapy either curative or palliative
• Radiotherapy treatment involving the routine acquisition of CBCT for patient setup provided that 4DCBCT is to be acquired during the course of treatment.
• At least two radiotherapy fractions during the course of treatment.

You may not qualify if:

• Pregnant women.
• Patient who in the opinion of the treating physician could not tolerate the extra time on the treatment couch for two days of treatment.

Sponsors & Collaborators

• University of Sydney: lead
• National Health and Medical Research Council, Australia: collaborator
• Liverpool Cancer Therapy Centre: collaborator

Study Sites (1)

Liverpool Hospital

Liverpool, New South Wales, 2170, Australia

Location

Related Publications (1)

• Lau BKF, Reynolds T, Keall PJ, Sonke JJ, Vinod SK, Dillon O, O'Brien RT. Reducing 4DCBCT imaging dose and time: exploring the limits of adaptive acquisition and motion compensated reconstruction. Phys Med Biol. 2022 Mar 7;67(6). doi: 10.1088/1361-6560/ac55a4.

  PMID: 35172286 DERIVED

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ricky O'Brien, PhD

  University of Sydney

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 13, 2019
• First Posted: August 28, 2019
• Study Start: August 21, 2019
• Primary Completion: January 13, 2021
• Study Completion: February 19, 2021
• Last Updated: May 19, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will become available following completion of the final analysis. Data will be available indefinitely.
• Access Criteria: Data will be made available to other researchers upon request.

Locations

AU (1)