Laser Therapy on Orthodontic Tooth Movement
The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement
1 other identifier
interventional
24
1 country
1
Brief Summary
The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2014
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 6, 2018
CompletedFirst Submitted
Initial submission to the registry
August 15, 2019
CompletedFirst Posted
Study publicly available on registry
August 28, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
September 16, 2019
CompletedSeptember 24, 2020
September 1, 2020
4.8 years
August 15, 2019
September 16, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Rate of orthodontic tooth movement, with and without low-level laser therapy
The canine retraction was measured with a digital dynamometer
The quantification of OTM was performed before canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy
The canine retraction was measured with a digital dynamometer
The quantification of OTM was performed after 1 month of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy
The canine retraction was measured with a digital dynamometer
The quantification of OTM was performed after 2 months of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy
The canine retraction was measured with a digital dynamometer
The quantification of OTM was performed after 3 months of canine retraction
Secondary Outcomes (1)
Chemokine levels in the periodontal tissue after LLLT and orthodontic force
The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy
Study Arms (5)
Low-level laser therapy and no orthodontic force
EXPERIMENTALNo orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours
Low-level laser therapy and application of orthodontic force
EXPERIMENTALOrthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours
Orthodontic force only
ACTIVE COMPARATOROrthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy
Low-level laser therapy and orthodontic force
EXPERIMENTALOrthodontic force and Laser is applied and the orthodontic tooth movement is evaluated
Orthodontic force with no laser therapy
ACTIVE COMPARATOROrthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy
Interventions
Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons
Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement
Eligibility Criteria
You may qualify if:
- Facial convexity
- Protrusion or biprotrusion of the incisors
- Dental crowding
- Healthy periodontal condition
- Satisfactory oral hygiene
You may not qualify if:
- Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months
- Skeletal crossbite
- Parafunctional habits
- Occlusal interference
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Pontifical Catholic University of Minas Gerais
Belo Horizonte, Minas Gerais, 30535-901, Brazil
Related Publications (5)
Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.
PMID: 22381489BACKGROUNDAlhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.
PMID: 10505748BACKGROUNDTorri S, Weber JB. Influence of low-level laser therapy on the rate of orthodontic movement: a literature review. Photomed Laser Surg. 2013 Sep;31(9):411-21. doi: 10.1089/pho.2013.3497. Epub 2013 Jul 24.
PMID: 23883115BACKGROUNDGenc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013 Jan;28(1):41-7. doi: 10.1007/s10103-012-1059-6. Epub 2012 Feb 18.
PMID: 22350425BACKGROUNDKim SJ, Moon SU, Kang SG, Park YG. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009 Sep;41(7):524-33. doi: 10.1002/lsm.20792.
PMID: 19639625BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
August 15, 2019
First Posted
August 28, 2019
Study Start
February 1, 2014
Primary Completion
November 6, 2018
Study Completion
September 16, 2019
Last Updated
September 24, 2020
Record last verified: 2020-09
Data Sharing
- IPD Sharing
- Will not share